暖心胶囊对两种心衰模型大鼠心功能的影响  

Effect of Nuanxin Capsule on Two Rat Models with Heart Failure

作　　者：周才杰 李俊[3] 廖雪珍[4] 廖惠芳[4] 王帅[4] 赖小平[4] 邱书奇 

机构地区：[1]深圳市耳鼻咽喉研究所,广东深圳518116 [2]深圳龙岗中心医院耳鼻喉科医院,广东深圳518116 [3]广东省中医院急诊科,广东广州510120 [4]广州中医药大学,广东广州510006

出　　处：《中药材》2011年第7期1081-1085,共5页Journal of Chinese Medicinal Materials

摘　　要：目的:观察暖心胶囊对腹主动脉狭窄和阿霉素诱导的两种心衰模型大鼠心功能的影响。方法:采用腹主动脉狭窄和腹腔注射阿霉素诱导法分别复制心衰大鼠模型,将造模成功大鼠随机分为模型组,暖心胶囊低、高剂量组及地高辛组,并分别设假手术组和正常对照组;给药30 d后,检测各组大鼠心率(HR)、外周收缩压(SBP)、外周舒张压(DBP)、左室收缩压(LVSP)、左室舒张末压(LVEDP)、左室内压上升/下降最大速率(±dp/dt)、外周平均动脉压(MBP)、血清血管紧张素Ⅱ(AngⅡ)、超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量,并计算心脏指数,测量心脏体积。结果:暖心胶囊低、高剂量可升高腹主动脉狭窄心衰模型大鼠SBP、LVSP、±dp/dt,降低LVEDP,增加SOD活性,降低MDA含量,与模型组比较有显著性差异(均P<0.05),并可不同程度减慢心率,但与模型组比较无显著性差异(P>0.05)。同时能降低阿霉素诱导的心衰模型大鼠的心率,缩小心脏体积,降低心脏系数,与地高辛组比较无显著性差异(P>0.05),并能显著降低心衰模型大鼠血清AngⅡ含量,其中暖心胶囊高剂量还能升高阿霉素心衰模型大鼠MBP、升高血清SOD的活性,与模型组比较差异显著(P<0.01)。结论:暖心胶囊对阿霉素和腹主动脉狭窄诱导的两种心衰大鼠模型均有较好的治疗作用。Objective：To observe the effects of Nuanxin Capsule（NC）on the rat models of heart failure induced by abdominal aorta constriction and adriamycin.Methods：Rats were randomly divided into the following groups： model control group,low-dose and high-dose,and digoxin group.Meanwhile,the pseudo-operation and NC groups were seperately established.After treatment for 30 days,the heart rate,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,left ventricular systolic pressure（LVSP）,left ventricular end-diastolic pressure（LVEDP）,maximal rate of increase and decrease in left ventricular pressure（±dp/dt）,mean peripheral blood pressure（MBP）as well as levels of serum superoxide dismustase（SOD）,malondialdeh-vde（MDA）,cardiac index and heart size were measured.Results：SBP,LVSP,±dp/dt and SOD activity increased,while LVEDP,serum MDA levels decreased in high and low-dose NC groups of two models.The heart rates also decreased,but the difference was insignificant（P〈0.05,compared with those of model group）.Besides,the heart rate,heart size and cardiac index,as well as serum AngⅡlevels also decreased.The differences were significant as compared with the digoxin group（P〈0.05）.The high-dose NC also significatly improved MBP and SOD（P〈0.05 and P〈0.01）.Conclusion：Nuanxin Capsule has good therapeutic effects on the rats models of adriamycin and abdominal aorta constriction induced heart failure.

关 键 词：暖心胶囊 充血性心力衰竭 阿霉素 腹主动脉狭窄 大鼠 

分 类 号：R285.5[医药卫生—中药学]