脑钠肽在急性心肌梗死患者中的变化及与左室重构的关系  

The relationship between serum BNP level and the left ventricular remodeling in patients with acute myocardial infarction

作　　者：景宏美[1] 秦小同[1] 袁鼎山[2] 吴晓晖[1] 陆齐[1] 李爱林[2] 朱健华[1] 瞿玲谦[1] 

机构地区：[1]南通大学附属医院心内科,南通226001 [2]南通大学附属医院急诊科,南通226001

出　　处：《南通大学学报（医学版）》2011年第4期254-256,共3页Journal of Nantong University(Medical sciences)

基　　金：南通市应用研究资助项目(K2009061)

摘　　要：目的:探讨急性心肌梗死(AMI)患者早期脑钠肽(BNP)水平与左室重构的关系。方法:选择AMI患者(60例)和对照组(22例)在入院后(24 h内)采用酶联免疫法(ELISA)测定血清BNP浓度,入院后第7～10天内行心脏超声检查,测量左室收缩末期容积(LVESV)和舒张末期容积(LVEDV)及左室射血分数(LVEF),观察BNP水平与AMI患者心功能,心肌梗死范围及左室重构指标LVESV、LVEDV和LVEF的关系。结果:AMI患者心功能越差,心肌梗死范围越大,BNP浓度越高(P<0.01);血清BNP水平与LVESV、LVEDV呈正相关,与LVEF呈负相关。结论:急性心梗后BNP水平升高与左室重构相关。Objective： To explore the correlation between serum BNP level and left ventricular remodeling in patients with acute myocardial infarction（AMI）.Methods： Serum BNP level was determined by ELISA in 60 consecutive in patients with AMI and 22 normal control group.Patients were grouped according Killip grades, the indexes of left ventricular remodeling clude left ventricular end diastolic volume（LVEDV）,left ventricular end systolic volume（LVESV） and left ventricular eject fraction（LVEF） were measured by ultrasonic cardiogram on day 7～10.The relationship were obtained between serum BNP level and cardiac function,infarction areas and the left ventricular remodeling in patients with acute myocardial infarction.Results： The serum BNP level was significantly higher with the cardiac function（killips grades） worse and the infarction areas increased（all P〈0.01）.The serum BNP level in hospitalized patients with AMI was positively correlated with LVESV and LVEDV,negatively correlated with LVEF.Conclusion： The serum BNP level in patients with AMI was correlated with left ventricular remodeling.

关 键 词：急性心肌梗死 脑钠肽 左室重构 

分 类 号：R542.2[医药卫生—心血管疾病]