CETP基因I405V突变位点多态性与冠心病关系的再探讨  

Correlation between polymorphism of mutable point in I405V of CETP gene and CHD

作　　者：周代锋[1] 张勇[2] 蔡苗[1] 麦明晓[1] 张云霞[1] 

机构地区：[1]海南医学院生物化学教研室,海南海口571101 [2]海南省老年病医院,海南海口571101

出　　处：《海南医学院学报》2011年第10期1297-1299,共3页Journal of Hainan Medical University

基　　金：海南省科技计划资助项目(ZDXM20090805);海南医学院生物化学与分子生物学重点学科项目;海南省老龄办资助项目;海南省自然科学基金立项课题(NO.80311)~~

摘　　要：目的:以百岁老人为健康对照对CETP基因I405V突变位点多态性与冠心病关系进行再探讨。方法:利用等位基因特异性PCR技术,对334例海南汉族CHD患者及276名百岁健康老人CETP基因I405V突变位点多态性进行检测,并利用SPSS13.0软件对检测结果进行统计学分析。结果:两组I405V基因型及等位基因频率分布比较差异具有统计学意义(χ2分别为55.923和28.885,P均<0.001)。结论:CETP基因I405V突变位点多态性与冠心病有着显著关联性,等位基因I对心血管有保护作用,而突变型等位基因V可能是冠心病易感基因。Objective： To investigate the correlation between polymorphism of mutable point in I405V of Cholesterol ester transfer protein（CETP） gene and coronary artery disease（CHD）.Methods： Polymorphism of mutable point in I405V of CETP was detected by allele specific-PCR（AS-PCR） in 334 CHD patients and 276 centenarians.The frequency of the genotype and allele were calculated and compared by SPSS13.0.Results： Frequency of the genotype and the allele in 334 CHD patients were significantly different from those in the healthy controls（centenarians）（χ2=55.923,P0.001;χ2=28.885,P0.001）.Conclusions： I405V polymorphism in CETP gene is closely related to CHD.The V allele is the susceptibility gene,and I allele shows protective effects.

关 键 词：胆固醇酯转运蛋白基因 DNA态性 冠状动脉粥样硬化性心脏病 

分 类 号：R541.4[医药卫生—心血管疾病]