低风险饮酒对丙泊酚镇静效应的影响  

The influence on the sedative effects of propofol in patients with low risk alcohol intake

作　　者：范涛[1] 宣燕[1] 华玉思[1] 郑宏[1] 

机构地区：[1]新疆医科大学第一附属医院麻醉科,乌鲁木齐市830011

出　　处：《临床麻醉学杂志》2011年第8期752-754,共3页Journal of Clinical Anesthesiology

基　　金：新疆维吾尔自治区自然科学基金(2009211B19);新疆维吾尔自治区重点学科(外科学)建设经费(2004-2008)

摘　　要：目的探讨低风险饮酒对丙泊酚靶控输注（TCI）镇静效应的影响。方法全麻择期手术患者71例，ASAⅠ或Ⅱ级，年龄18-59岁，分为低风险饮酒组（D组，n=38）和非饮酒组（N组，n=33）。术前受试对象均排除相关非处理因素，仅接受丙泊酚TCI镇静，血浆药物浓度设置为3．5μg／ml。观察并记录两组每分钟的HR、SpO2、NIBP、反应熵（RE）、状态熵（SE），以及警觉／镇静（0AA／S）评分、靶效应室药物浓度、停药后靶血浆药物浓度的衰减和不良事件的发生率，OAA／S评分达0分所用时间，OAA／S评分达0分所需丙泊酚用量、血浆靶浓度与效应室靶浓度平衡即刻停药至0AA／S评分恢复为5分所用时间。结果两组患者RE、SE随时间变化趋势相同。OAA／S评分达0分所用时间D组为（402±198）S，N组为（503±255）S，达0分所需丙泊酚用量D组为（2．131±0．663）mg／kg，N组为（2．397±0．746）mg／kg，OAA／s评分恢复为5分所用时间D组为（481±184）s，N组为（521±166）s。结论低风险饮酒的患者对丙泊酚TCI镇静效应无明显影响。Objective To study the influence of low risk alcohol intake on the sedative effects of propofol with TCI （Target-controlled Infusion）. Methods Seventy-one ASA I or II patients, aged 18-59 years, scheduled for elective surgery under general anesthesia were enrolled in this study and divided into two g.roups： low risk drinking group（group D,n=38） and non-drinking group（group N, n= 33）. All patients were sedated by only propofol before surgery, and the target plasma concentration was 3. 5μg/ml. NIBP（Non-invasive Blood Pressure）, HR, SpO2, response entropy （RE）, state entropy （SE）, the Modified Observer＇s Assessment of Alertness/Sedation（OAA/S） score, target effect site concentration of propofol, target plasma concentration of propofol after stopping TCI, and the time when OAA/S score was 0, the dosage（mg/kg） of propofol when OAA/S was 0, the time when OAA/S returned to 5 in both groups were recorded. Results There was no difference between two groups in the changes of RE and SE. The time when OAA/S scale reached 0 was（402±198） s in group D and（503 ±255）s in group N; The dosage of propofol when OAA/S scale reached 0 was（2. 131±0. 663）mg/kg in group D and（2. 397±0. 746）mg/kg in group N; The time when OAA/S returned to 5 was（481±184）s in group D and（521±166）s in group D. Conclusion The sedation effects of propofol by TCI have no significant influence in patients with low risk alcohol intake.

关 键 词：低风险饮酒 靶控输注 丙泊酚 镇静 

分 类 号：R614[医药卫生—麻醉学]