大孔树脂使用次数对羟基红花黄色素A吸附率的影响  

Influence of Reusing Time of Macroporous Resin on Adsorption Rate of HSYA A

作　　者：孙永成[1] 郭传宝[1] 王伟[1] 颜丙鹏[1] 尚强[1] 景娇[1] 萧伟[1] 

机构地区：[1]江苏康缘药业股份有限公司中药制药过程新技术国家重点实验室,连云港222001

出　　处：《世界科学技术-中医药现代化》2011年第4期697-699,共3页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家重大新药创新项目(2011ZX09401-097):中药治疗心血管疾病有效成分组(群)的创新药物孵化基地;负责人:萧伟

摘　　要：目的:考察D101大孔吸附树脂使用次数对羟基红花黄色素A吸附率的影响,为产业化生产提供依据。方法:采用静态吸附法,对反复再生后的D101大孔吸附树脂衰减规律进行了研究,并采用高效液相色谱法对羟基红花黄色素A含量进行了定量分析。结果:D101大孔吸附树脂在经过乙醇、2%盐酸、5%氢氧化钠反复再生后,使用16次吸附率下降约27%。结论:D101大孔吸附树脂在活化再生使用16次以后,不宜再用。This study aimed to investigate the influence of reusing time of D101 macroporous resin on the adsorption rate of HSYA A in order to provide basis for industrial production. Static adsorption was used in the study on attenuation of repeated regeneration D101 macroporous resin. High Performance Liquid Chromatography （HPLC） was applied in the quantitative analysis of HSYA A contents. The results showed that through the repeated regeneration processed by ethanol, 2% hydrochloric acid and 5% sodium hydroxide, after 16 times using, the adsorption rate of D101 macroporous decreased by about 27%. It is concluded that D101 macroporous resin after regeneration and reactivation can be used for no more than 16 times.

关 键 词：羟基红花黄色素A 大孔树脂 静态吸附 

分 类 号：R969[医药卫生—药理学]