芪穹胶囊对大鼠局部脑缺血再灌注损伤的保护作用  

The protective effects of Qiqiong Capsule on focal cerebral ischemia/reperfusion injury

作　　者：任于果[1] 李侠[2] 黄欢[2] 尹艳艳[2] 李维祖[2] 

机构地区：[1]安徽医科大学第一附属医院神经内科,安徽省合肥230032 [2]安徽医科大学药理学教研室,抗炎免疫药理学省部共建教育部重点实验室,国家中医药管理局中药药理三级实验室

出　　处：《中国基层医药》2011年第16期2184-2186,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨芪穹胶囊（QQJN）对局部脑缺血再灌注损伤的保护作用及其机制。方法采用大鼠线栓法制备局脑缺血再灌注模型，观察QQJN对神经功能评分、脑梗死百分比、脑组织病理形态学、脑组织SOD活性、MDA含量、体外血栓形成及血小板聚集的影响。结果与模型组比较，QQJN（4．4、8．8g／kg）对脑缺血再灌注8h和22h的神经功能评分有一定的降低作用，可以减少脑梗死百分比，不同程度的改善脑组织病理形态学的变化；QQJN（4．4,8．8g/kg）可以增加脑组织SOD活性，降低MDA含量，具有抑制体外血栓形成和血小板聚集等作用。结论QQJN对局脑缺血再灌注损伤具有一定的保护作用，其机制可能与抗自由基损伤、抑制血小板聚集、血栓形成等有关。Objective To study the protective effects of Qiqiong（QQJN） on focal cerebral ischemia/reperfu- sion injury and its mechanism. Methods Middle cerebral artery occlusion（MCAO） was used to make focal cerebral ischemia/reperfusion model by intravascular nylon filament occlusion. The protective effects of QQJN were evaluated by investigating neurological function score, percentage of cerebral infarction, pathomorphology of brain, the activity of SOD and the content of MDA in brain tissue, thrombogenesis and platelet aggregation in vitro. Results Compared with model group,QQJN（4.4,8.8g/kg）could decrease the neurological score in 8 and 22h after reperfusion, reduce the percentage of cerebral infarction, improve pathomorphology of brain, decrease the length, wet weight and dry weight of thromb and inhibit platelet aggregation. Conclusion QQJN had protective effects on focal cerebral isehemia/reper- fusion injury. The role of anti-injury of free radicals,inhibit thrombogenesis and platelet aggregation should contribute to its neuroprotective effects.

关 键 词：脑缺血再灌注损伤 自由基 血栓形成 血小板聚集 

分 类 号：R28[医药卫生—中药学]