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机构地区:[1]滨州市人民医院内分泌科,山东省滨州256610
出 处:《中国基层医药》2011年第17期2327-2328,共2页Chinese Journal of Primary Medicine and Pharmacy
摘 要:目的观察甲状腺功能减退症(甲减)患者激素替代治疗前后血脂和心肌酶谱的变化及意义。方法检测72例甲减患者(观察组)治疗前后和60例健康对照组血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL—C)、天门冬氨酸转氨酶(AST)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(HBDH)和肌酸肌酶同工酶(CKMB)水平。结果观察组治疗前TC、TG和LDL-C水平均明显高于对照组(均P〈0.05),而治疗后水平明显下降(均P〈0.05),略高于对照组,但差异无统计学意义(均P〉0.05)。观察组治疗前AST、LDH、HBDH和CKMB水平明显高于对照组(均P〈0.05),而治疗后AST、LDH、HBDH和CKMB水平明显下降(均P〈0.05),治疗后AST、LDH、HBDH和CKMB水平与对照组比较,差异无统计学意义(均P〉0.05)。结论甲减患者经激素替代治疗后血脂和心肌酶谱基本恢复正常,对于防治心血管疾病具有重要意义。Objective To observe the changes and significance of blood fat and myocardial enzymes in patients with hypothyroid myopathy before and after substitutional treatment. Methods The levels of TC, TG, LDL-C, AST, LDH, HBDH and CKMB were detected in 72 cases with hypothyroid myopathy patients before and after substitutional treatment and 60 healthy controls. Results The levels of TC, TG and LDL-C in hypothyroid myopathy patients before substitutional treatment were significantly higher than those in control group ( all P 〈 0. 05 ), and then signitlcandy low after treatment,which had no significant difference with control group( all P 〉 0. 05 ). The levels of AST, LDH,HBDH and CKMB in hypothyroid myopathy patients before substitutional treatment were significantly higher than.those in control group( all P 〈0. 05) ,and then significantly low after treatment, which had no significant difference with control group( all P 〉0. 05). Conclusion The levels of blood fat and myocardial enzymes were significantly increased in hypothyroid myopathypatients,and recovery to normal after substitutional treatment.
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