抗氧化低密度脂蛋白自身抗体与2型糖尿病动脉粥样硬化关系的研究  

Study on the Relationship of Autoantibodies Against Oxidative Low-Density-Lipoprotein and Type 2 Diabetic Artherosclerosis

作　　者：麦麦提热夏提·沙吾提[1] 吐尔逊江·司拉木[2] 杜春辉[3] 田刚[4] 

机构地区：[1]新疆喀什地区第一人民医院CCU室,新疆喀什844000 [2]新疆喀什地区第一人民医院血液科,新疆喀什844000 [3]新疆喀什地区第一人民医院检验科,新疆喀什844000 [4]天津公安医院检验科,天津300040

出　　处：《现代检验医学杂志》2011年第4期73-74,共2页Journal of Modern Laboratory Medicine

摘　　要：目的探讨抗氧化低密度脂蛋白自身抗体在T2DMAS发生发展中的作用及其关系。方法采用7ml／dlPEG沉淀法获得免疫复合物，应用抗氧化低密度脂蛋白自身抗体（OX-LDL-Ab）酶联免疫测定方法对40例正常对照组、50例T2DM无AS组、30例T2DM有AS组患者血清中抗氧化低密度脂蛋白免疫复合物（0X—LDL—IC）中0X—LDL—Ab进行测定。结果正常对照组与T2DM无AS组比较0X—LDL—Ab阳性率和含量水平差异均无统计学显著性意义（t=2．54，t=1．64，P〉0．05），正常对照组与T2DM有AS组比较则差异有统计学显著性意义（t=64．22，t=34．92，P〈O．01），T2DM无AS组与T2DM有AS组比较差异也有统计学显著性意义（t=53．73，t=35．89，P〈0．01）。结论：OX—LDL—Ab可作为早期诊断和防治糖尿病有无动脉粥样硬化的一个可靠指标。Objective To investigate the relationship between autoantibodies against Oxidative Low-Density-Lipoprotein （OX-LDL-Ab） and type 2 diabetic artherosclerosis. Methods 80 patients with suspected AS were devided into two groups. By 7 ml/dl PEG praecipitatum and ELISA assay,isolate and determinate OX-LDL-Ab in immunocomplex between group T2DM and control group. Results Comparing group T2DM-accompanying AS to control group and to T2DM-noncomitant AS group ,level and positive rate of OX-LDL-Ab was elevated significantly in T2DM-aceompanying AS group （t = 64.22,t=34.92;t=53. 73,t=35.89;P〈0. 01）;Comparing group T2DM-noncomitant AS to control group,level and positive rate of OX-LDL-Ab was not elevated significantly in T2DM-noncomitant AS group （t=2.54,t=1.64,P〉0.05）. Conclusion Detection of OX-LDL-Ab could be applied in the early diagnosis of type 2 diabetes whether or not accompanying AS to help treat the disease.

关 键 词：抗氧化低密度脂蛋白自身抗体 2型糖尿病 动脉粥样硬化 

分 类 号：R587.2[医药卫生—内分泌] R392.11[医药卫生—内科学]