糖尿病患者检测β_2-微球蛋白的临床意义  

The clinical significance to detect the β_2-MG of diabetic patients

作　　者：孙东兵[1] 

机构地区：[1]山东省单县中心医院核医学科,山东单县274300

出　　处：《中国医药导报》2011年第25期145-146,共2页China Medical Herald

摘　　要：目的:探讨血、尿β2-微球蛋白(β2-MG)对糖尿病患者的临床意义。方法:用放射免疫方法测定糖尿病患者血、尿β2-MG的水平。结果:糖尿病患者血、尿β2-MG含量明显高于健康人员(P<0.01),且随着病程的延长,血、尿β2-MG的含量明显增加;血、尿β2-MG的含量在非胰岛素依赖性糖尿病(NIDDM)和胰岛素依赖性糖尿病(IDDM)患者之间比较,差异无统计学意义(P>0.05)。结论:测定糖尿病患者血、尿β2-MG对早期发现、预防和治疗糖尿病肾病有重要的临床意义。Objective： To study the clinical significance to detect the blood and urine β2-microglobulin protein （β2-MG）of diabetic patients. Methods： The levels of blood and urine β2-MG of diabetic patients were measured by radioimmunoassay. Results： The levels of blood and urine β2-MG of diabetic patients were significantly higher than health people in the control group （P〈0.01）, and the levels of blood and urine β2-MG were significantly increased with the duration of the exten- sion. There was no statistically significant difference between non-insulin-dependent diabetes mellitus （NIDDM） and insulin-dependent diabetes mellitus （IDDM） patients in levels of blood and urine β2-MG （P〉0.05）. Conclusion： It has an important clinical significance of diabetic patients to determine the levels of blood and urine β2-MG on the early detection to prevent and treat the diabetic nephropathy.

关 键 词：糖尿病 Β2-微球蛋白 糖尿病肾病 

分 类 号：R446.112[医药卫生—诊断学]