肠道菌群与儿童免疫  

作　　者：曹海宁[1] 周昌宁[2] 

机构地区：[1]遵义医学院生化与分子生物学教研室,563003 [2]南华大学附一医院烧伤科,421001

出　　处：《当代医学》2011年第26期24-26,共3页Contemporary Medicine

摘　　要：人体内存在数量庞大、结构复杂的正常肠道菌群,其在长期的历史进化过程中形成了一个动态的微生态系统。像是一道屏障,保护宿主的健康,维持人体肠道正常生理功能。肠壁内存在为数众多、功能强大的淋巴细胞,以肠粘膜为界,两者相互作用,相互制约,处于动态平衡状态。正常肠道菌群在促进免疫系统发育,维持正常免疫功能,协同拮抗病原菌入侵方面,发挥着重要作用。同时,免疫系统对肠道菌群又有制约和调控作用,如对正常菌表现为免疫耐受,对病原菌表现为免疫排斥,一旦二者间的平衡被破坏,就会导致疾病。The human body coexisted with a complex array of commensal bacterial flora that colonizes the gastrointestinal tract is formed a dynamic micro-ecological system developed during evolution process. As a barrier, the normal flora in human intestinal tract protect the host from infection and other diseases and maintain the normal physiological function of human intestine. The intestinal mucosa contains a large number of different lymphocytes, which interact with intestinal microflora, plays a significant role in the development of the immune system, maintenance of intestinal immune homeostasis and protection against invasion by pathogens. Meanwhile, the intestinal commensal microflora also fulfills a host of useful functions, including stimulating and modulating development and function of the intestinal and systemic immune system; repressing the growth of harmful microorganisms; training the immune system to responsd only to pathogens and preventing allergy.

关 键 词：肠道菌群 粘膜免疫 儿童 

分 类 号：R725.7[医药卫生—儿科]