高分子囊泡和空心球的制备和几个研究亮点  

PREPARATION AND SOME RESEARCH HIGHLIGHTS OF POLYMER VESICLES AND HOLLOW SPHERES

作　　者：刘晓霞[1] 江明[1] 

机构地区：[1]聚合物分子工程教育部重点实验室复旦大学高分子科学系,上海200433

出　　处：《高分子学报》2011年第9期1007-1019,共13页Acta Polymerica Sinica

基　　金：国家自然科学基金(基金号50333010;20834004;20774021)资助项目

摘　　要：聚合物囊泡和空心球是具有重要理论研究价值和在很多领域特别是在生物医药方面具有潜在应用的大分子组装体.本文综述了高分子囊泡及空心球的制备方法及某些新发展.其传统的制备方法主要包括嵌段共聚物自组装法和聚合物胶束去核法以及模板上合成.着重讨论了近年来新发展起来的非共价键合自组装法(NCCM)以及通过化学反应一步从单体获得聚合物空心球法等.这些新方法可以克服传统方法需要预组织结构及去核等的繁琐步骤.还对近年来囊泡功能化方面的几个典型研究如胶束-囊泡转变、呼吸囊泡和囊泡崩解及囊泡表面的修饰进行了评述.Polymer vesicles or hollow spheres as macromolecular self-assemblies are of great importance in theoretical studies as well as broad applications,especially in medicine fields.In this article,discussions on different routes of preparation of polymer vesicles or hollow spheres were presented.The traditional preparation methods for the assemblies include self-assembly of block copolymers,shell crosslinking and core removal of copolymer micelles and synthesis on the templates.The methods via non-covalently connected micelles（NCCM）,as well as the one-step synthesis from monomers to polymer vesicles were reviewed in detail.These methods have overcome the laborious multistep processes including using a preorganized structure and subsequent removal of the core or templates et al.Recent progresses in functional block copolymer vesicles,such as the micelle-vesicle transition,＂breathing＂ vesicles,bursting of sensitive polymersomes and surface modification of polymeric vesicles have been highlighted.

关 键 词：聚合物囊泡 空心球 制备方法 功能化 

分 类 号：O631.3[理学—高分子化学]