心脑血管用药不良反应与用药人群间的关联关系分析  

Analysis of Association between Adverse Drug Reactions Induced by Cardiovascular and Cerebrovascular Drugs and Patients

作　　者：冯变玲[1,2] 魏芬[2] 杨世民[2] 赵君[2] 雷祎[2] 覃蓝[2] 

机构地区：[1]天津大学药物科学与技术学院,天津市300072 [2]西安交通大学医学院药学系,西安市710061

出　　处：《中国药房》2011年第36期3389-3391,共3页China Pharmacy

基　　金：陕西省卫生厅卫生科研基金资助项目(2010D33)

摘　　要：目的:分析药品不良反应与用药人群的性别、年龄间潜在的关联关系,为心脑血管类疾病用药的安全、合理、有效提供参考。方法:根据江苏省药品不良反应监测中心2004-2009年收集的9640份心脑血管疾病用药不良反应报告数据,运用数据挖掘技术中广义规则归纳法(GRI)的关联规则算法对数据进行分析。从年龄、性别支持度,不同不良反应现象与不同年龄段间关联关系的置信度以及不同不良反应现象与不同性别间关联关系的置信度进行分析,得出相关结果。结果与结论:药品不良反应主要发生在2个年龄段,一是50～59岁年龄段,不良反应主要为咳嗽和头晕;二是60～69岁年龄段,不良反应主要为头晕和恶心。药品不良反应在男性身上发生的频次较女性多;个别不良反应有较明显的性别偏向。OBJECTIVE：To explore potential correlation of adverse drug reaction（ADR） with patient＇s gender and age,and to provide the best evidence for medical staff to making decision to ensure that security of drug use for cardiovascular and cerebrovascular diseases and improve therapeutic efficacy.METHODS：9 640 ADR reports on drug use for cardiovascular and cerebrovascular diseases were collected from Jiangsu Province Adverse Drug Reaction Monitoring Centre during 2004-2009.GRI association rules algorithm of data mining technology was used for data analysis.RESULTS：During 2004-2009,data was analyzed from support of age and gender,confidence level of association of different ADR phenomena with different age groups and confidence level of association of different ADR phenomenon with gender.Related results were obtained.CONCLUSION：The ADR mainly occurred in two age groups,50～59 age group and ADR included coughing and dizziness;60～69 age group and ADR included dizziness and nausea.ADR occurred in more male than female;individual ADR were more obvious gender bias,such as cough mainly in male,headache,dizziness,nausea and vomiting mainly in female.

关 键 词：心脑血管用药 不良反应 用药人群 关联关系 分析 

分 类 号：R95[医药卫生—药学]