厄贝沙坦联合氨氯地平治疗高血压肾病的疗效观察  

Efficacy Observation on Hypertensive Renal Disease Treated with Irbesartan and Amlodipin

作　　者：吴文利[1] 罗羽慧[1] 金平[1] 

机构地区：[1]重庆市中山医院心内科,重庆市400013

出　　处：《中国药房》2011年第36期3400-3402,共3页China Pharmacy

摘　　要：目的:观察厄贝沙坦联合氨氯地平治疗高血压肾病的临床疗效。方法:将我院诊断为高血压肾病的患者300例,随机B1:组1:。1分3组为均3治组疗:A4组周口,观服察厄治贝疗沙前坦后1530组m患g,者qd收;B缩组压口、服舒氨张氯压地、尿平素5氮mg、,血qd肌;C酐组、2采4h用尿厄蛋贝白沙定坦量联治合疗氨效氯果地。平结治果疗:,治用疗法后用3量组同患A者、收缩压、舒张压和24h尿蛋白定量均明显降低(P<0.05);与A、B组比较,C组降低更为显著(P<0.01)。3组均未见严重不良反应发生。结论:厄贝沙坦联合氨氯地平治疗高血压肾病疗效及安全性较好,可有效控制血压及降低24h尿蛋白。OBJECTIVE：To observe the effect of Irbesartan and amlodipine on hypertensive renal disease.METHODS：300 patients with hypertensive renal disease were divided into 3 groups randomly,the changes of systolic blood pressure,diastolic blood pressure,blood urea nitrogen,serum creatinine,24 h urinary protein during treatment before and after 4 weeks treated with irbesartan（group A,150 mg,qd）,Amlodipine（group B,5 mg,qd） or Combination of irbesartan and amlodipine（group C,the usage was same to group A,B） were analyzed.RESULTS：The results show that systolic blood pressure,diastolic blood pressure and 24 h urinary protein of patients were significantly decreased after treatment with irbesartan and amlodipine（P0.01）.There was no serious ADR found among 3 groups.CONCLUSION：The treatment of hypertensive renal disease with Combination of irbesartan and amlodipine is better,which can effectively control the level of blood pressure and reduce 24 h urinary protein.

关 键 词：高血压肾病 厄贝沙坦 氨氯地平 

分 类 号：R969.4[医药卫生—药理学]