广西莪术的化学成分研究(英文)  

Chemical Constituents from the Rhizomes of Curcuma kwangsiensis

作　　者：李军[1,2] 刘越[1,2] 李建强[1,2] 陈丽霞[1,2] 赵锋[3] 邱峰[1,2] 

机构地区：[1]沈阳药科大学中药学院,沈阳110016 [2]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,沈阳110016 [3]烟台大学药学院,烟台264005

出　　处：《中国天然药物》2011年第5期329-333,共5页

基　　金：supported by National Key Science and Technology Special Project (No. 2009ZX09301-012);Program for Liaoning Excellent Talents in University (No.LR201037)~~

摘　　要：目的:对广西莪术(Curcuma kwangsiensis)的根茎进行化学成分研究。方法:运用硅胶、Sephadex LH-20柱色谱、ODS柱色谱和制备HPLC等分离手段进行化学成分的分离纯化,根据其波谱数据鉴定其结构。结果:从广西莪术中分离得到 7个化合物,分别鉴定为:[4-(1′-hydroxy-1′-methylethyl) benzoate-1′-O-β-D-glucopyranoside](1),[4-(1′-hydroxy-1′-methylethyl) ben-zoic acid-1′-O-β-D-glucopyranoside](2),2, 3,5-trihydroxy-1-(3-methoxy-4-hydroxyphenyl)-7-(3,5-dimethoxy-4-hydroxyphenyl) hep-tane(3) and 2,3, 5-trihydroxy-1-(4-hydroxyphenyl)-7-(3,5-dimethoxy-4-hydroxyphenyl)heptane(4),以及 1,5-epoxy-3α-hydroxy- 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(3,4-dihydroxy)heptane(5),(3R′,5S′)-3,5-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(3,4-dihydroxyphenyl) heptane(6),2,4,6-trihydroxyacetophenone-2,4-di-O-β-D-glucopyranoside(7)。结论:化合物1-4为新化合物,化合物3-7对脂多糖所致巨噬细胞产生一氧化氮表现出强的抑制活性。AIM： To study the bioactive constituents of Curcuma kwangsiensis. METHODS： The compounds were isolated by silica gel, Sephadex LH-20, and Rp-18 gel column chromatography, and preparative HPLC. The smactures were elucidated by extensive spectroscopic methods including 2D-NMR and HRESI-MS. RESULTS： Four new compounds, methyl p-（1-β-D-glucopyranosyloxy-l-methylethyl） benzoate （1）, p-（1-β-D-glucopyranosyloxy-l-methylethyl） benzoic acid （2）, 2, 3, 5-trihydroxy-1-（3-methoxy-4- hydroxyphenyl）-7-（3, 5-dimethoxy-4-hydroxyphenyl） heptane （3）, and 2, 3, 5-trihydroxy-1-（4-hydroxyphenyl）-7-（3, 5-dimethoxy-4-hydroxyphenyl） heptane （4）, and three known ones, 1, 5-epoxy-3u-hydroxy-l-（3, 4-dihydroxy-5-methoxy-phenyl）-7-（3, 4-dihydroxy） heptane （5）, （3R＇, 5S＇）-3, 5-dihydroxy-l-（4-hydroxy-3-methoxyphenyl）-7-（3, 4-dihydroxyphenyl） heptane （6）, and 2, 4, 6-trihydroxyacetophenone-2, 4-di-O-β-D-glucopyranoside （7）, were isolated. CONCLUSION： Compounds 1-4 were new natural compounds, and 3-7 showed strong inhibitory effects on NO production induced bv LPS in macroohages.

关 键 词：广西莪术 化学成分 二苯庚烷类 一氧化氮 巨噬细胞 

分 类 号：R284.1[医药卫生—中药学]