BNP与CA125检测在诊断慢性心力衰竭中的价值  

The Significance of the Determination of Plasma BNP and CA125 in Patients with Chronic Heart Failure

作　　者：孙伟莉[1] 李卫鹏[1] 袁媛[1] 陶健[1] 宣玲[2] 何娟娟[1] 

机构地区：[1]安徽省蚌埠医学院第一附属医院核医学科,233004 [2]安徽省蚌埠医学院第一附属医院心血管科,233004

出　　处：《中华全科医学》2011年第10期1528-1529,共2页Chinese Journal of General Practice

摘　　要：目的探讨血浆中脑钠肽(BNP)和CA125的水平在诊断慢性心力衰竭(CHF)中的价值。方法 89例经临床确诊为慢性心力衰竭并按照纽约心脏协会(NYHA)分级区分其心衰程度的患者作为研究对象,同时选取26例健康体检人员作为对照组;采用化学免疫发光法定量测定血浆中BNP以及CA125水平;将不同组间的BNP及CA125值进行比较,并做相关性分析。结果 CHF组血浆BNP与CA125水平在心功能不同级别之间比较,差异均有统计学意义(P<0.05),并且各组间与对照组间差异均有统计学意义(P均<0.05);BNP或CA125水平与左室射血分数LVEF呈显著负相关(r值分别是-0.83和-0.61,P<0.05)。结论血浆BNP与CA125值在CHF患者中升高并与NYHA分级有明显的相关性,可作为诊断心力衰竭的有价值指标,并可用于评判慢性心力衰竭的临床治疗效果。Objective To investigate the clinical value of BNP and CA125 in patients with chronic heart failure.Methods 89 patients diagnosed as chronic heart failure（CHF） were recruited;patients were grouped according to the New York Heart Association（NYHA） classification.26 healthy people were set as controls.The plasma BNP and CA125 were determined by chemiluminescent immunoassay.The levels of BNP and CA125 between different groups were compared,and the correlation was analyzed.Results Both of the differences of BNP and CA125 between different groups were significant（P0.01）.The plasma levels of BNP and CA125 in CHF patients were negatively correlated to LVEF（r=-0.87 and-0.61,P0.05）.Conclusion Levels of BNP and CA125 were correlated to NYHA classification in patients with CHF.They can be used as valuable indexes in the diagnosis and treatment of CHF.

关 键 词：BNP CA125 慢性心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]