脑外伤病人GFAP水平变化及依达拉奉疗效研究  

Study on serum GFAP change and therapeutic effect of edaravone in patients with traumatic brain injury

作　　者：揭波盛[1] 

机构地区：[1]浙江省常山县人民医院,常山324200

出　　处：《浙江创伤外科》2011年第4期446-448,共3页Zhejiang Journal of Traumatic Surgery

摘　　要：目的观察脑外伤病人血清胶质纤维酸性蛋白(GFAP)水平变化及依达拉奉的治疗效果。方法 80例颅脑外伤行急诊手术病人随机分为观察组与对照组,每组各40例。观察组除常规治疗外,静脉滴注依达拉奉。测定两组病人术后第1、3、7、14天两组血清GFAP蛋白水平;记录治疗后3个月时的GOS评分。结果观察组术后第3、7天GFAP蛋白水平显著低于对照组(t=2.865,P<0.05;t=3.147,P<0.05);观察组术后3个月GOS评分明显高于对照组(t=2.164,P<0.05)。术后第3天GFAP蛋白水平与术后3个月GOS评分呈显著负相关(r=-0.287,P<0.05)。结论依达拉奉对脑外伤病人有一定疗效,血清GFAP水平与预后相关,值得在临床上应用。Objective To investigate the serum glial fibrillary acidic protein （GFAP） change and the therapeutic effect of edaravone in patients with traumatic brain injury. Methods 80 patients with traumatic brain injury and emergency surgery were randomly divided into two groups （observation group and control group）. There were 40 patients in each group. The patients of observation group were treated with edaravone intravenously. The serum GFAP levels in i ,3,7,14 days after surgery and the GOS scores 3 months after treatment were observed. Results The serum GFAP level of the observation group was significantly lower than that of the control group in 3,7 days after surgery （t=2.865, P〈0.05 ; t=3.147, P〈 0.05）. The GOS score of the observation group was significantly higher than that of the control group （t=2.164, P〈0.05）. The serum GFAP level in 3 days after surgery was significantly negatively correlated with the GOS score 3 months after treatment （r=-0.287,P〈0.05）. Conclusion Edaravone is efficacious on patients with traumatic brain injury. Serum GFAP was correlated with the prognosis and could be applicated clinically.

关 键 词：依达拉奉 脑外伤 胶质纤维酸性蛋白 

分 类 号：R651.15[医药卫生—外科学]