心周脂肪组织与冠心病及代谢综合征的关系  

The relationship of pericardial adipose tissue volume with coronary artery disease and metabolic syndrome

作　　者：刘瑛琪[1] 费军[2] 刘莉[1] 刘军华[1] 王晓非[1] 郑冬[2] 张朝利[2] 

机构地区：[1]解放军306医院心内科,北京100101 [2]解放军306医院影像科,北京100101

出　　处：《中华老年心脑血管病杂志》2011年第9期781-783,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨心周脂肪组织(pericardial adipose tissue,PAT)容量与冠心病及代谢综合征(metabo1ic syndrome,MS)的关系。方法回顾性分析1102例患者的双源CT冠状动脉造影资料,采用平扫图像测定PAT容量。根据代谢危险因素的数量和冠状动脉狭窄程度,将患者分为MS组338例和无MS组764例及≥50%狭窄组492例和<50%狭窄组610例。结果 MS组PAT容量较无MS组明显增多,≥50%狭窄组PAT容量较<50%狭窄组明显增多(P<0.01)。随着代谢危险因素数目的增加,PAT容量呈上升趋势,差异有统计学意义(P<0.01)。多元回归分析显示,PAT容量与≥50%狭窄(回归系数=1 7.78,P<0.01)、体重指数(回归系数=7.32,P<0.01)、腹围(回归系数=2.51,P<0.01)和LDL-C(回归系数=16.94,P<0.05)相关。结论多层螺旋CT测定PAT容量是提示患者冠心病和代谢风险的方法之一。Objective To study the relationship of volume of pericardial adipose tissue（PAT） with coronary artery disease and metabolic syndrome（MS）. Methods The computed tomography angiography data of 1102 consecutive patients were analyzed retrospectively. Pericardial adipose tissue volume was measured using non-enhanced image. According to the number of metabolic risk factors and the extent of coronary stenosis, the patients were divided into MS group （n = 338）and non-MS group （n = 764）,and ≥50% stenosis group （n = 492）or 〈50% stenosis group（n = 610）. Results Perieardial adipose tissue volume increased significantly in MS group compared with non-MS group. It also increased significantly in ≥50%stenosis group compared with 〈50 % stenosis group. As the number of metabolic risk factors increased, the volume of pericardial adipose tissue increased correspondingly. Multiple regression analysis showed that ≥50% stenosis （coefficient= 17.78, P 〈 0.01） ,BMI（coeffieient= 7.32, P〈 0.01） ,waist circumference（coefficient=2.51, P 〈 0.01） and LDL-C level（coefficient= 16.94, P 〈0.01） were correlated with pericardial adipose tissue volume. Conclusion MDCT measurement of perieardial adipose tissue volume could be applied as one of the indicators of coronary artery disease and metabolic risk.

关 键 词：脂肪组织 代谢疾病 体层摄影术 X线计算机 冠状血管造影术 危险因素 心周脂肪 

分 类 号：R541.4[医药卫生—心血管疾病] R589[医药卫生—内科学]