单分散介孔氧化硅纳米颗粒的制备及其在生物材料方面的应用  

Monodisperse Mesoporous Silica Nanoparticles:Synthesis and Application in Biomaterials

作　　者：唐诗洋[1] 孙晓君[1] 林丽[2] 孙艳[2] 刘献斌[1] 

机构地区：[1]哈尔滨理工大学化学与环境工程学院黑龙江省绿色化212技术重点实验室,哈尔滨150040 [2]哈尔滨工业大学生命科学与工程系,哈尔滨150001

出　　处：《化学进展》2011年第9期1973-1984,共12页Progress in Chemistry

基　　金：国家自然科学基金项目(No.30900336);教育部博士点基金项目(No.20092302120070)资助

摘　　要：单分散介孔氧化硅纳米颗粒由于其自身的优点,在当前许多领域有着广泛的应用前景。本文综述了近十几年来单分散介孔氧化硅纳米颗粒的制备方法以及在生物材料方面的应用。在制备方法方面,根据其制备机理分为稀溶液法、微乳法、模板剂法以及向反应体系中加入不同的添加剂等方法,制备出分散性好、不同形态、孔径尺寸可调的介孔氧化硅纳米颗粒。在生物材料的应用方面,主要介绍了其在药物与生物活性分子的负载与控制释放、生物大分子的固载与分离、生物标记与临床诊断等方面的应用。Monodisperse mesoporous silica nanoparticles are of promising applications in many current and emerging areas of technology because of their nature advantages.This review is devoted to the progress made in the last decade in synthesis and biomedical application of monodisperse mesoporous silica nanoparticles.We present a comprehensive overview of synthetic strategies for monodisperse mesoporous silica nanoparticles.These strategies are broadly categorized into three groups,such as dilute solution method,microemulsion method,and introduction of template/different additives to reaction system.Monodisperse mesoporous silica nanoparticles with good dispersion,different morphology and tuning pore sizes are successfully synthesized by means of the above-mentioned methods.Applications of monodisperse mesoporous silica nanoparticles in drug and large biomolecule delivery and controlled release,separation of the large biomolecule,biomarker and biomedical diagnosis are mostly described.

关 键 词：单分散 介孔氧化硅 纳米颗粒 制备 生物材料 

分 类 号：O613.72[理学—无机化学] TB383[理学—化学]