过量ROS／RNS引发的线粒体功能：障碍与代谢性心血管病及中药介入  

Mitochondrial dysfunction induced by excessive ROS/RNS-metabolic cardiovascular disease and traditional Chinese medicines intervention

作　　者：张晨晨[1] 刘俊[1] 潘会君[1] 杨晓露[1] 卞卡[1,2] 

机构地区：[1]上海中医药大学穆拉德中药现代化研究中心,上海201203 [2]美国德克萨斯大学休斯敦医学院综合生物及药理学系,德克萨斯大学分子医学研究所,美国休斯敦TX77030

出　　处：《中国中药杂志》2011年第17期2423-2428,共6页China Journal of Chinese Materia Medica

基　　金：国家科技部“十一五”科技支撑计划项目(2006BAI11B08-03);上海市教委高校一氧化氮与炎症医学E研究院计划项目(E-04010);上海市科委国际技术转移项目(08430711300);上海市科委中药现代化项目(08DZ1972104)

摘　　要：代谢性心血管病是以机体糖类或脂质代谢紊乱为主要病因的一类心血管疾病,其中2型糖尿病又是典型的代谢性疾病,它不仅会使人产生胰岛素抵抗,更与动脉粥样硬化有关。由活性氧/活性氮产生的氧化应激是引起动脉粥样硬化的一个重要因素,而线粒体不仅是活性氧/活性氮的来源,更是其作用靶点,现有证据表明,线粒体功能障碍是导致心血管损伤的一种机制。文章从活性氧/氮所引发的线粒体功能障碍入手,介绍了二者过量后所激发的线粒体凋亡通路对动脉粥样硬化的影响,就二者通过影响脂质代谢及诱发2型糖尿病,继而产生心血管疾病做一综述,并介绍了麦冬、紫铆亭、人参、葛根和白毛藤等数味中药通过抗ROS/RNS及影响线粒体凋亡通路,从而达到治疗作用。而且以上诸味中药还有诸如抗癌和抗疲劳等作用,有别于经典西药作用的单一性,显示了中药作用的多面性。Metabolic cardiovascular disease is a type of disease which almost caused by body carbohydrate and lipid metabolism dysfunction. Type 2 diabetes mellitus is a typical metabolic disease. It not only lead to the insulin resistance but also related to atherosclerosis. Oxidative stress is produced by the reactive oxygen/nitrogen species （ROS/RNS） . Oxidative stress and its consequence events play important roles in atherosclerosis （AS）. Mitochondria are both sources and targets of reactive oxygen and/or nitrogen species （ROS/RNS）, and there is growing evidence that mitochondrial dysfunction may be relevant intermediate mechanism by which cardiovascular risk factors lead to the formation of vascular lesions. Several cardiovascular risk factors are demonstrated causes of mitochondrial damage. This review starts with excessive ROS/RNS-induced mitochondrial dysfunction. The authors emphasize the relationship among axis of excessive ROS/RNS-mitochondrial dysfunction-apoptosis-atherosclerosis. They also introduce several traditional Chinese medicines such as Ophiopogon japonicus, butin, Panax ginseng, Pueraria lobata, Solanum lyratum and so on in the treatment of relevant diseases through anti-ROS/RNS mechanism. Moreover, the TCMs also can anti-cancer and anti-fatigue,which show the speciality of TCMs different from the single effect of classical western medicines.

关 键 词：活性氧/活性氮 线粒体功能障碍 凋亡 动脉粥样硬化 中药 

分 类 号：R54[医药卫生—心血管疾病]