氟伐他汀钠-PLGA微球复合膜的制备及体外缓释药的研究  

Preparation and property of sustained release in vitro of Fluvastatin-PLGA microspheres compound membrane

作　　者：高志达[1] 杨茂伟[1] 梁栋[1] 杨蕾[1] 

机构地区：[1]中国医科大学附属第一医院骨科,辽宁沈阳110001

出　　处：《中国现代医学杂志》2011年第23期2851-2854,共4页China Journal of Modern Medicine

基　　金：辽宁省博士启动基金资助项目(No:20071044);辽宁省科学技术计划项目(No:2009225025);沈阳市科学技术计划项目(No:1091136-9-03)

摘　　要：目的制备氟伐他汀钠-PLGA微球复合薄膜,并对其体外释药性能进行相关评价。方法用复乳法制备3种不同含药量的氟伐他汀钠-PLGA微球,压膜后在PBS缓冲液中进行体外缓释药实验,使用高效液相色谱法(HLPC)绘制累积释药曲线。结果分别用50、75和125mg氟伐他汀钠制作不同含药量的微球复合膜。其28d内累积释放量分别为95.49%、96.40%和98.45%,在5～28d释药后期药物释放平稳而缓慢。结论制备得到了缓释时间为28d的氟伐他汀钠-PLGA微球复合膜,其缓释时间及缓释特性能够满足下一步的动物体内实验,具有潜在的临床应用需要。【Objective】 To prepare a Fluvastatin carried system by PLGA microspheres compound membrane and study the delivery of Fluvastatin from PLGA compound membrane in vitro so as to choose better carrier.【Methods】 Three different Fluvastatin sodium-loaded microspheres were made using a triple emulsion process.After membrane in PBS buffer a drug delivering experiments carried out in vitro,draw the curve of accumulative release rate on time by high performance liquid chromatography（HLPC）.【Results】 With 75 mg,50 mg,and 125 mg Fluvastatin sodium make different doses of containing microspheres composite film.Accumulation release percent contents of Fluvastatin in microspheres compound membrane 28 days range from 95.49%~98.45%,and in the later stage（5~28 d）,all the implants exhibit stable and slow release behavior.【Conclusion】 Fluvastatin-PLGA microspheres compound membrane were formulated successfully.Moreover,the release time could meet the requirement for the next step in animal experiment and have potential clinical application needs.

关 键 词：氟化他汀 微球复合膜 体外释药 缓释 

分 类 号：R944.9[医药卫生—药剂学] R972.6[医药卫生—药学]