静脉桥动脉化后桥血管重塑的实验研究  

Experimental study of arterialized vein graft remodeling

作　　者：赵智伟[1] 葛建军[1] 林敏[1] 周正春[1] 王海涛[1] 孔祥[1] 刘永志[1] 邬松[1] 周经月[1] Abendroth DK 

机构地区：[1]安徽医科大学第一附属医院,合肥230022 [2]德国Ulm大学临床外科中心

出　　处：《山东医药》2011年第32期20-22,119,共4页Shandong Medical Journal

基　　金：安徽省科技厅重点项目(07020303071)

摘　　要：目的探讨静脉动脉化(AVG)对静脉桥血管结构重塑的影响。方法将30只SD大鼠随机分为实验组和对照组。实验组采用改良cuff法构建颈AVG模型,对照组仅模拟手术环境,切开和缝合皮肤、分离动静脉,未进行AVG。分别于术后1、2、4周取出静脉桥及对照组颈静脉,进行形态学分析,研究桥血管内膜和中膜的增生变化。结果 2组模型均无动物死亡。4周时实验组1只闭塞,通畅率93.3%。实验组1、2、4周时内膜及中膜均较对照组增厚(P<0.05或<0.01)。结论 AVG使静脉桥血管内膜及中膜增生,加快了静脉桥血管的结构重塑。Objective To investigate the effect of vein graft arterialization on vein graft remodeling.Methods Thirty SD rats were randomly divided into the AVG group and the CON group.We established vein graft arterialization model using inproved cuff technique in AVG group with the external jugular vein graft to the ipsilateral common carotid artery,but in CON group,only simulated surgical environment,cut and stitched the skin,separated artery and vein without the vein arterialization.Respectively,after 1 week,2 weeks,4 weeks vein grafts and the control veins were harvested,and intimal and medial hyperplasia were sdudied by morphological analysis.Results No animal died in two groups.There was only one case of vein occlusion in AVG group at 4 weeks,the patency rate was 93.3%.Intimal and medial of the AVG group were significantly thicker than those of the CON group（P0.05 or P0.01）.Conclusion AVG advances the intimal and medial hyperplasia,and accelerates vein grafts remodeling.

关 键 词：静脉桥 静脉动脉化 再狭窄 内膜 中膜 

分 类 号：R654.2[医药卫生—外科学]