冠心宁注射液联合缬沙坦治疗慢性肺源性心脏病急性加重期临床研究  

Clinical effect observation of Guanxinning injection combined with valsartan in the treatment of chronic pulmonary heart disease at acute exacerbation stage

作　　者：张郁[1] 李丽芬[1] 乔福斌 任丽霞[1] 陈娟[1] 

机构地区：[1]冀中能源邢台矿业集团总医院内二科,河北邢台054000

出　　处：《河北中医》2011年第8期1213-1214,1231,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的探讨冠心宁注射液联合缬沙坦治疗慢性肺源性心脏病急性加重期的临床疗效。方法将89例慢性肺源性心脏病急性加重期患者随机分为2组,对照组44例采用西医常规综合治疗,治疗组45例在对照组治疗基础上加用冠心宁注射液联合缬沙坦。2组均治疗3周,观察患者临床疗效及血气分析结果。结果治疗组总有效率86.7%,对照组总有效率65.9%,2组总有效率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组。2组血气指标治疗后较治疗前均明显改善(P<0.05),2组治疗后动脉血氧分压[p(O2)]、二氧化碳分压[p(CO2)]比较差异均有统计学意义(P<0.05)。结论冠心宁注射液联合缬沙坦治疗慢性肺源性心脏病急性加重期安全、有效,可明显改善慢性肺源性心脏病相关指标。Objective To explore the curative effect of Guanxinning injection combined with valsartan in the treatment of chronic pulmonary heart disease at acute exacerbation stage.Methods 89 patients with chronic pulmonary heart disease at acute exacerbation stage were randomly divided into two groups： the treatment group and the control group.44 cases in control group were treated by routine western medicine.45 patients in the treatment group were treated by Guanxinning injection combined with valsartan on the basis of conventional western medicine.The course was three weeks in two groups.Clinical symptoms and indexes of blood gas analysis were observed.Results The total effective rate was 86.7% in the therapy group and 65.9% in the control group,there was significant difference between the two groups（P0.05）.The indexes of blood gas analysis were improved after treatment in two groups（P0.05）.There was significant difference between two groups on p（O2） and p（CO2） after treatment（P0.05）.Conclusion Guanxinning injection combined with valsartan is safe and effective in treating chronic pulmonary heart disease at acute exacerbation stage,it can greatly improve the relative index of chronic pulmonary heart disease.

关 键 词：肺心病 中西医结合疗法 急性病 慢性病心血管药物(中药) 四唑类 缬氨酸 

分 类 号：R287[医药卫生—中药学] R977.4[医药卫生—中医学]