天麻成分C小鼠灌胃的急性毒性与催眠作用  

Acute toxicity and mesmerism of component C of tall gastrodia rhizome by administered mouse intragastrically

作　　者：何晓山[1] 张志朋[1] 山培理[1] 李润梅[1] 刘红梅[1] 周正荣[1] 

机构地区：[1]云南中医学院药理学教研室,云南昆明650500

出　　处：《新乡医学院学报》2011年第5期551-553,共3页Journal of Xinxiang Medical University

基　　金：国家自然科学基金资助项目(编号:81060371);云南省科技计划资助项目(编号:2009ZC092M)

摘　　要：目的了解天麻成分C灌胃给药的急性毒性,及其对戊巴比妥钠致小鼠催眠作用的影响。方法选择无特定病原体(SPF)级昆明种小鼠为受试对象,采用一次性灌胃给药的急性毒性实验测定最大给药量;根据戊巴比妥钠致眠作用的影响来评价药物对中枢神经系统的作用。结果天麻成分C小鼠灌胃给药测不出半数致死量,未观察到明显毒性,其灌胃的最大给药量为9.09 g.kg-1。天麻成分C小鼠灌胃给药,单独使用不能引起小鼠睡眠,但可以使戊巴比妥钠腹腔注射引起的小鼠睡眠作用增强,睡眠潜伏期缩短,睡眠持续时间延长。结论天麻成分C对中枢神经系统可能有一定的抑制作用,不能直接引起小鼠睡眠,但可增强戊巴比妥钠对小鼠的催眠作用。Objective To understand the message of acute toxicity of component C of tall gastrodia rhizome by administered mouse intragastrically and observe its influence on mesmerism induced by pentobarbital sodium. Methods Specific pathogen free level Kunming mice were choosen as subjects.The maximum administration dose was tested by one-time oral administration acute toxicity testing.The effect of component C of tall gastrodia rhizome on central nervous system of mice was evaluated with mesmerism induced by suprathreshold dose and subthreshold dose of pentobarbital sodium. Results The mice were intragastric administration component C of tall gastrodia rhizome could not determine the medial lethal dose,and no significant toxicity was observed.The maximum administration dose of component C of tall gastrodia rhizome is intragastrically 9.09 g·kg-1.Component C of tall gastrodia rhizome cann′t cause mice to sleep,but can strengthen mice′s sleep induced by pentobarbital sodium and shorten sleep latency and lengthen sleep time. Conclusion Component C of tall gastrodia rhizome has some inhibitory action on central nervous system of mouse.It can not cause mice to sleep,but can strengthen mice′s sleep induced by pentobarbital sodium.

关 键 词：天麻 急性毒性 催眠作用 戊巴比妥钠 

分 类 号：R965[医药卫生—药理学]