差示分光光度法测定盐酸异丙嗪糖浆中盐酸异丙嗪含量  

Determination of Promethazine Hydrochloride in Promethazine Hydrochloride Syrup by Differential Spectrophotometry

作　　者：王芳[1] 宋光伟[1] 刘晓方[1] 曹健[1] 

机构地区：[1]第三军医大学新桥医院药学部,重庆400037

出　　处：《中国药业》2011年第17期26-27,共2页China Pharmaceuticals

摘　　要：目的建立测定盐酸异丙嗪糖浆中盐酸异丙嗪含量的差示分光光度法。方法采用差示分光光度法,检测波长为336.5 nm。结果盐酸异丙嗪检测质量浓度在10.00～50.02μg/mL范围内与差示吸光度值线性关系良好(r=0.999 9);平均回收率为99.82%,RSD=0.23%(n=6)。结论所用方法操作简便、准确可靠、重复性好、专属性强,可用于该制剂的质量控制。Objective To establish a differential spectrophotometry method for determining the content of the promethazine hydrochloride in its syrup.Methods The content of promethazine hydrochloride was examined by utilizing differential spectrophotometry at the detection wavelength of 336.5 nm.Results There was a good linear relationship in the concentration range of 10.00-50.02 μg/mL（r=0.999 9）;the average recovery rate was 99.82%,RSD=0.23%（n=6）.Conclusion It is a simple,accurate,reliable,reproducible and specific method for determining the promethazine hydrochloride in its syrup.

关 键 词：盐酸异丙嗪糖浆 盐酸异丙嗪 差示分光光度法 含量测定 

分 类 号：R927.2[医药卫生—药学] R976