还原型谷胱甘肽治疗慢性铅中毒合并肝脏损害42例  

Reduced Glutathione in Treating Chronic Lead Poisoning Combined with Liver Injury in 42 Cases

作　　者：张少俭[1] 

机构地区：[1]陕西省宝鸡市妇幼保健院内科,陕西宝鸡721000

出　　处：《中国药业》2011年第17期63-64,共2页China Pharmaceuticals

摘　　要：目的观察还原型谷胱甘肽(GSH)对慢性职业性铅中毒肝脏损害的肝功能改善作用。方法对42例慢性铅中毒合并肝脏损害患者,给予5%葡萄糖注射液250 mL+还原型谷胱甘肽2.4 g静脉滴注,1次/d,连用7 d为1个疗程;5%葡萄糖注射液500 mL+依地酸二钠钙1.0 g静脉滴注,1次/d,连用3 d,停4 d为1个疗程。每个疗程结束后测定血铅值,复查肝功能。结果 42例患者经1～3个疗程治疗后,肝功能全部恢复正常,血铅值均降至400μg/L以下。结论还原型谷胱甘肽治疗慢性铅中毒合并肝脏损害疗效确切,值得临床推广,还应作为解毒药在络合剂驱铅治疗时联合应用。Objective To survey the improving effect of reduced glutathione（GSH）on chronic occupational lead poisoning liver injury hepatocyte.Methods For the 42 patients suffering chronic lead poisoning liver injury,intravenous inject 250 mL of 5%glucose and 2.4 of GSH once per day,continuously 7 d for 1 course of treatment.Intravenous injecting 500 mL of 5%glucose and 1.0 of calcium sodium edentate once per day,continuously 3 d injection and 4 d without injection for 1 course of treatment.After every course of treatment,measure the lead value in blood and check the silver function.Results After 1～3 courses,the 42 patients recovered with the lead value in blood reduced below 400 μg/L.Conclusion It is true that GSH is effective to chronic lead poisoning liver injury.The method is worthy to spread in clinical practice,and which should be jointly used as antidotum in complexing agent driving lead therapy.

关 键 词：还原型谷胱甘肽 慢性铅中毒 肝脏损害 保肝治疗 

分 类 号：R969.4[医药卫生—药理学] R975.5[医药卫生—药学]