中药治疗小儿迁延性慢性腹泻文献的系统评价  

Chinese medical herbs for children’s persistent diarrhea: a systematic review

作　　者：石文韬[1] 何倩雯[1] 梁筱[1] 李继强[1] 刘劲 张洁[1] 高嗣法[1] 魏蕾[1] 

机构地区：[1]武汉大学,武汉430071 [2]宁波经济技术开发区医院,宁波315207

出　　处：《中华中医药杂志》2011年第9期2121-2125,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：湖北省科技厅科技计划项目(No.2009CDA074);中央高校基本科研业务费专项资金(No.20083010201000069)~~

摘　　要：目的:评价中药治疗小儿迁延性慢性腹泻的疗效和安全性,并分析其用药规律,为今后的实验科研设计及治疗提供参考。方法:采用计算机检索与手工检索相结合的方法,全面收集中药治疗小儿迁延性慢性腹泻的随机与半随机对照试验。结果:共25篇文献进入研究,共计2 802人,Meta分析显示治疗组较对照组有统计学意义(Z=7.79,P<0.00001),且副作用较小;另分析用药情况得知,燥湿健脾类中药在本病治疗中使用频率最高,温中散寒、行气化滞、利水渗湿、涩肠止泻之品药亦有较高的使用频率。结论:中药治疗小儿迁延性慢性腹泻疗效较好,无明显不良反应,中药配伍体现了治法上主要采用益气健脾、渗湿化滞法,而病程较长者,常采用温肾健脾、涩肠止泻法。Objective： To systematically assess the effect of Chinese medical herbs on children with persistent diarrhea and to analyze the law of herbs in treatment.Methods： The trials of Chinese herbs for children＇s persistent diarrhea were collected by electronic retrieval tools in Cochrane Library,Medline,EMBASE,CBM database,CNKI database,VIP database and by hand in some Chinese journals and books.Meanwhile,we assessed the quality in accordance with the following criteria： randomized controlled trials and quasi-randomized controlled trials in the participants,comparing Chinese traditional medical herbs with some other treatments.Results： 25 literatures were brought into the studies totally with 2 802 cases（1 500 in treatment group and 1 302 in controlled group）.The data of meta-analysis showed that the difference between the treatment group and control group was significant（Z=7.79,P〈0.00001） and with less side effects.We analyzed all the prescription-formulating principles and found that the herbs for drying dampness and strengthening the spleen were frequency of use.Some other traditional herbs（such as herbs for warming meridians to dissipate cold,herbs for promoting circulation of qi,diuretics for eliminating dampness,et al） were applied in high frequency.Conclusion： Chinese medical herbs were effective and safe for children＇s persistent diarrhea,whatever the routes of administration were,the effective rate of treatment groups was obvious with less side reaction comparing with controlled groups.Only because of the limited quantity and low quality,the RCTs with high quality evidence were still being needed for the further study.

关 键 词：中药 迁延性腹泻 慢性腹泻 随机对照试验 系统评价 

分 类 号：R272[医药卫生—中医儿科学]