肝硬化患者发生肝肾综合征的危险因素分析  

The analysis of risk factor of hepatorenalsyndrome in the cirrhosis patients

作　　者：刘正刚 

机构地区：[1]广东省东莞市大朗人民医院,广东东莞523770

出　　处：《中国当代医药》2011年第10期37-39,共3页China Modern Medicine

摘　　要：目的:肝肾综合征(hepatorenalsyndrome,HRS)是各种肝病晚期的严重并发症,死亡率很高,预后极差,目前尚无有效的治疗措施。因此,预防HRS的发生发展是临床工作中的重要问题。由此设想,如果明确了HRS发生的危险因素,就可以对患者进行针对性的治疗以预防HRS的发生。本研究目的是探讨引起HRS的危险因素,防止HRS的发生。方法:对本院慢性肝病住院患者进行回顾性队列研究。对比在治疗过程中发生HRS患者和未发生HRS的患者,选择16个可能引起HRS的临床及理化指标,通过单因素和多因素分析,了解在HRS发生过程中的危险因素。结果:经过筛选结果显示,肝功能分级(Chlid-Pugh评分)、MELD指数、感染、PTA、放腹水次数、利尿剂量和是否行扩溶治疗,差异有统计学意义(P<0.05),为主要危险因素。结论:改善患者的肝功能状态,合理的利尿剂和使用抗生素,有助于防止HRS的发生。Objectives：Hepatorenal syndrome was a form of acute or sub-acute renal failure which develops in patients with chronic liver disease.In contrast to other forms of acute renal failure it may be reversible.But there was still no effictive treament to it.So it was most important to prevent the occurrence.The aim of this study was to invetigate the dangerous factors.Methods：A retospective study was carried out.16 possible dangerous factors including clinical and physiochemical features were analyaed between patients with cirrhosis and patients who underwent hepatorenal syndrome.Logistic regression analysis,chi-square test and indepentdent-t rest were used in our research.Results：From the logistic regression,Chlid-Pugh score,MELD index,infection,PTA,frequency of releasing abdominal,dropsy dosage of diuretica,liquid therap was the major risk factor of the patorenal syndome.Conclusion：The hepatorenal syndrome can be prevented by impoving liver function,reasonable using of the diuretic and antibiotics.

关 键 词：肝硬化 肝肾综合征 危险因素 肝病晚期 

分 类 号：R657.31[医药卫生—外科学]