HPLC法测定盐酸氟桂利嗪口腔崩解片的含量  

HPLC Determination of Flunarizine Hydrochloride Orally Disintegrating Tablets

作　　者：王景翔[1,2] 牟微[1] 曹德英[2] 汤旭婷[1] 

机构地区：[1]石家庄学院化工学院,河北石家庄050035 [2]河北医科大学药学院,河北石家庄050017

出　　处：《中国当代医药》2011年第11期5-6,共2页China Modern Medicine

摘　　要：目的:建立盐酸氟桂利嗪口腔崩解片的HPLC含量测定方法。方法:采用shimadzu ODS C18色谱柱(150.0 mm×4.6 mm,5μm);流动相为甲醇-磷酸二氢钾(0.01 mol/L,pH=3.5)(68∶32);流速为1.0 ml/min;检测波长为254 nm;柱温:30℃。结果:盐酸氟桂利嗪浓度为4.8～57.6μg/ml线性关系良好(r=0.999 9);平均回收率为100.27%,RSD为1.00%(n=9)。结论:本方法简便、灵敏,精密度高,重现性好,可用于盐酸氟桂利嗪口腔崩解片的含量测定。Objective： To establish HPLC determination method of Flunarizine Hydrochloride orally disintegrating tablets. Methods： HPLC analysis was carried out by using shimadzu ODS C18 column （150.0 mm×4.6 mm, 5μm）. Mobile phase was methanol-potassium dihydrogen phosphate （0.01 mol/L, pH=3.5）（68：32）; The flow rate was 1.0 ml/min. The detection wavelength was set at 254 nm and the column temperature was 30℃. Results： There was a good linear relationship for flu- narizine hydrochloride in the range of 4.8-57.6 μg/ml（r=0.999 9）. The average recovery was 100.27% （n=9） and RSD was 1.00%. Conclusion： This method is simple, sensitive, and accurate with good reproducibility. It can be used for the content determination for Flunarizine Hydrochloride orally disintegrating tablets.

关 键 词：盐酸氟桂利嗪 口腔崩解片 高效液相色谱法 含量测定 

分 类 号：R286.0[医药卫生—中药学]