敬钊毒素-V对吗啡成瘾小鼠戒断症状的影响  

Effects of JZTX-V on withdrawl symptoms in morphine dependent mice

作　　者：徐德宏[1] 陈仁忠[1] 池宇朋[1] 蔡丽君[1] 文宁[2] 肖玉成[1] 王贤纯[1] 曾雄智[1] 梁宋平[1] 

机构地区：[1]湖南师范大学蛋白质化学与发育生物学教育部重点实验室,湖南长沙410081 [2]湖南中医药大学,湖南长沙410208

出　　处：《湖南中医药大学学报》2011年第7期11-13,共3页Journal of Hunan University of Chinese Medicine

基　　金：国家973项目(2009CB526510;2010CB529800);863项目(2006AA02Z141);湖南省自然科学基金资助项目(07JJ3072);教育部新世纪优秀人才支持计划(NCET-07-0279)资助;湖南省教育厅重点项目(OTA035)

摘　　要：目的观察Jingzhaotoxin-V敬钊毒素-V(JZTX-V)对纳洛酮催促戒断症状的治疗作用。方法建立吗啡成瘾小鼠模型,分别测定4组不同剂量5,50,500,1000μg/kg JZTX-V对小鼠戒断后跳跃次数的影响。结果 JZTX-V在戒断后的15min内能减少小鼠的跳跃次数,而且5、50和500μg/kg JZTX-V对跳跃次数的抑制具有统计学意义(P<0.05、P<0.01)。结论 JZTX-V在5-500μg/kg范围内能显著抑制小鼠戒断后的跳跃次数,有可能成为一种戒毒先导分子。Objective To observe the treatment effects of Jingzhaotoxin-V（JZTX-V） on withdrawl symptoms aroused by Naloxone precipitation.Methods The mice models with morphine addiction were divided in 5,50,500 and 1000 μg/kg JZTX-V groups and each dose affected on the jumping times of mice after withdrawl.Results The JZTX-V reduced the jumping times of mice during the 15 minutes after withdrawl,and the doses 5,50 and 500 μg/kg JZTX-V were significant to inhibit the jumping times（P0.05 and P0.01）.Conclusion When the doses between 5 and 500 μg/kg,JZTX-V can significantly reduce jumping times of mice after withdrawl,which may be a leading molecule to be getting rid of drugs.

关 键 词：敬钊毒素-V 吗啡依赖 戒断症状 纳洛酮 小鼠 

分 类 号：R285.5[医药卫生—中药学]