白细胞介素6基因多态性与冠心病易感性的Meta分析  

Association of interleukin-6 gene polymorphisms with susceptibility to coronary heart disease:A meta-analysis

作　　者：高敏[1] 邹延峰[1] 冯晓亮[1] 潘发明[1] 苏虹[1] 范引光[1] 王静[1] 张承业[1] 叶冬青[1] 

机构地区：[1]安徽医科大学公共卫生学院流行病与卫生统计学系,合肥230032

出　　处：《中国临床保健杂志》2011年第4期360-364,共5页Chinese Journal of Clinical Healthcare

基　　金：国家自然科学基金重点项目(30830089)

摘　　要：目的对白细胞介素(IL)6基因多态性与亚洲人冠心病的关联性进行Meta分析。方法检索PubMed、Elsevier Science Direct、Cochrane Library、中国生物医学文献数据库、万方数据库和中国期刊全文数据库,收集探讨IL-6基因多态性与冠心病关联性的病例对照研究,剔除不符合要求的研究,应用RevMan4.2软件进行Meta分析。结果共11个研究(1821例病例和2453例对照)符合纳入标准。11个研究包括8个在中国,1个在韩国,1个在日本和1个在印度。IL-6基因三个多态性(-572C/G,-174G/C和-634C/G)适合进行Meta分析。Meta分析结果显示在亚洲人中-572C/G多态性和冠心病之间存在关联(GvsC,P=0.00;CG+GGvsCC,P<0.01;GGvsCC+CG,P=0.00;GGvsCC,P=0.00;CGvsCC,P<0.01)。对于-634C/G多态性,Meta分析也显示了类似的关联(GvsC,P=0.01;CG+GGvsCC,P=0.24;GGvsCC+CG,P=0.00;GGvsCC,P=0.00;CGvsCC,P=0.83)。但在亚洲人中-174G/C多态性和冠心病之间无关联(P>0.05)。结论亚洲人中IL-6基因-572C/G和-634C/G多态性与冠心病之间存在关联,而-174G/C多态性和冠心病之间无关联。Objective To quantitatively summarize the association of interleukin-6 gene polymorphisms with coronary heart disease using meta-analysis.Methods We surveyed studies on the association of interleukin-6 gene polymorphisms with coronary heart disease in Pubmed,Elsevier Science Direct,Cochrane Library,Chinese Biomedical Literature Database,Wanfang and China National Knowledge Infrastructure.All articles were strictly evaluated and screened according to inclusion criteria,and meta-analysis were perfomed for the included studies using RevMan 4.2 software.Results We identified 11 studies（1821 cases and 2453 controls）using search.Of eligible studies,8 studies were conducted in Chinese,1 studies were conducted in Korean,1 studies were conducted in Japanese,1 studies were conducted in Indian.Meta-analysis was performed for three interleukin-6 gene polymorphisms（-572C/G,-174G/C,and-634C/G）.Significant association was seen for-572C/G polymorphism（G vs C,P=0.0002;CG＋GG vs CC,P〈0.01;GG vs CC＋CG,P=0.00;GG vs CC,P=0.00;CG vs CC,P〈0.01）and-634C/G polymorphism（G vs C,P=0.01;CG＋GG vs CC,P=0.24;GG vs CC＋CG,P=0.00;GG vs CC,P=0.00;CG vs CC,P=0.83）in interleukin-6 gene,but not for-174G/C polymorphism（P〈0.05）.Conclusions Coronary heart disease is associated with interleukin-6 gene-572C/G and-634C/G polymorphisms,but not-174G/C.

关 键 词：冠心病 白细胞介素6 多态现象 遗传 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]