TRP channels in prostate cancer： the good, the bad and the ugly？  

作　　者：Dimitra Gkika Natalia Prevarskaya 

机构地区：[1]llnserm U1003, Equipe labellisee par la Ligue Nationale contre le cancer, Villeneuve d＇Ascq, France [2]Universite des Sciences et Technologies de Lille （USTL）, Villeneuve d＇Ascq, France

出　　处：《Asian Journal of Andrology》2011年第5期673-676,共4页亚洲男性学杂志（英文版）

摘　　要：During the last decade, transient receptor potential （TRP） channels emerge as key proteins in central mechanisms of the carcinogenesis such as cell proliferation, apoptosis and migration. Initial studies showed that expression profile of some TRP channels, notably TRP melastatin 8 （TRPM8）, TRP vanilloid 6 （TRPV6）,TRP canonical （TRPC6） and TRPV2, is changing during the development and the progression of prostate cancer towards the hormone-refractory stages. The link between the change in expression levels and the functional role of these channels in prostate cancer is step by step being elucidated. These recent advances are here described and discussed.During the last decade, transient receptor potential （TRP） channels emerge as key proteins in central mechanisms of the carcinogenesis such as cell proliferation, apoptosis and migration. Initial studies showed that expression profile of some TRP channels, notably TRP melastatin 8 （TRPM8）, TRP vanilloid 6 （TRPV6）,TRP canonical （TRPC6） and TRPV2, is changing during the development and the progression of prostate cancer towards the hormone-refractory stages. The link between the change in expression levels and the functional role of these channels in prostate cancer is step by step being elucidated. These recent advances are here described and discussed.

关 键 词：ion channel LYSOPHOSPHOLIPIDS migration NEUROENDOCRINE prostate cancer PSA transient receptor potential （TRP）channels TRP channels TRPM8 TRPV6 TRPV2 

分 类 号：Q78[生物学—分子生物学] TS943.31[轻工技术与工程—服装设计与工程]