水通道蛋白1在小鼠口腔粘膜表达与分布  

The expression and distribution of aquaporin-1 in the oral mucosa of mice

作　　者：谭美芸[1,2] 高俊英[1] 丁炯[1] 肖明[1] 

机构地区：[1]南京医科大学人体解剖学系,江苏南京210029 [2]江苏建康职业学院人体解剖学教研室,江苏南京210029

出　　处：《解剖科学进展》2011年第5期458-460,共3页Progress of Anatomical Sciences

基　　金：国家自然科学基金资助项目(No.07NMUM005)

摘　　要：目的观察水通道蛋白1(AQP1)在小鼠口腔粘膜的表达与分布,为研究AQP1在口腔水代谢和感觉传递中的作用提供形态学依据。方法制备成年小鼠口腔各部粘膜石蜡切片,进行AQP1免疫组织化学染色。结果 AQP1免疫阳性产物在唇、颊、硬腭、软腭和舌粘膜下层的毛细血管和神经纤维上广泛表达。另外在上述部位的腺泡和腺管周围的肌上皮细胞以及舌的味蕾和丝状乳头上也有AQP1免疫阳性信号。结论 AQP1在口腔广泛分布,可能参与了唾液分泌和口腔感觉传递等生理过程。Objective To study the expression and distribution of aquaporin-1 （AQP1） in the oral mucosa of mice to provide morphological basis for exploring the role of water channel protein AQP1 in water metabolism and sensory transduction of the oral cavity. Methods AQP1 immunostaining was performed on the paraffin sections of different parts of the oral mucosa of mice. Results AQP1 immunoreactive products were located in the capillaries and nervous fibers within the submucosa of lip, check, soft, hard palates and tongue. In addition, AQP1 labeling was also detected at myoepithelial cells surrounding the acini and small ducts within the above oral submucosa, filiform papillae and taste buds. Conclusions The extensive distribution of AQP1 in mucosa of the oral cavity suggests that it may play a kind of role in salivary secretion and thirst transduction.

关 键 词：水通道蛋白 口腔 小鼠 免疫组织化学 

分 类 号：Q591.2[生物学—生物化学]