幼年皮肌炎合并肺间质病变临床分析  

Clinical analyses of juvenile dermatomyositis complicated with interstitial lung disease

作　　者：邝伟英[1] 李彩凤[1] 何晓琥[1] 王江[1] 韩彤昕[1] 周怡芳[1] 

机构地区：[1]首都医科大学附属北京儿童医院风湿免疫科,100045

出　　处：《中国麻风皮肤病杂志》2011年第8期537-539,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的:分析幼年皮肌炎(JDM)合并肺间质病变(ILD)的临床特点。方法:回顾性分析94例JDM患者的临床、实验室检查和影像学资料及治疗和预后,对合并ILD和非合并ILD患者进行比较。结果:94例JDM患者中合并ILD 45例(47.9%)。合并ILD组关节炎所占比例高于无ILD组(P<0.05);ILD组患者的ANA阳性率、抗Jo-1抗体阳性率、RF阳性率与IgG升高率以及肌酸激酶(CK)均明显高于无ILD组(Ps<0.05);45例.JDM患者经治疗后41例病情改善,4例死于呼吸衰竭。结论:对JDM患者出现关节炎、IgG和CK升高时,应警惕合并ILD。Objective： To analyze the clinical characteristics of juvenile dermatomyositis （JDM） complicated with interstitial lung disease （ILD）. Methods： The clinical symptoms, laboratory tests, medical imaging profiles, and treatment and prognosis in 94 patients with JDM were analyzed. Comparison between the patients with ILD and with- out ILl） was made. Results： Forty- five （47.9%） out of 94 patients with JDM had ILD in the study group. Arthritis occurred more frequently in patients with ILD than those without ILD （P 〈 0.05）. The positivity rates of ANA, anti - Jo - 1 antibody, rheumatic factor, and elevation of IgG and CK were more frequently recorded in the patients with ILD than without ILD. In 45 patients with JDM - ILD, 41 recovered after treatment, 4 cases died of respiratory failure. Conclusion： The JDM patients should be suspected as having complication of ILD, when arthritis occurs and there is elevation of IgG, ESR and CK.

关 键 词：幼年皮肌炎 肺间质病变 

分 类 号：R593.26[医药卫生—内科学]