激光激活光敏剂ATX-S10和HpD特性的对比研究  

Different Properties of ATX-S10 and HpD Activated by Laser:an Experimental Research

作　　者：李维娜[1] 刘渊声[1] 杨继庆 屈学民[1] 文峻[1] 张敏[1] 

机构地区：[1]解放军第四军医大学数理教研室,西安市710032 [2]解放军第四军医大学口腔医院设备科

出　　处：《中国激光医学杂志》2011年第4期209-212,271,272,共6页Chinese Journal of Laser Medicine & Surgery

基　　金：国家自然科学基金资助项目(项目编号:10804129)

摘　　要：目的对比在激光辐射下ATX-S10和HpD两种光敏剂在其不同浓度及不同光照的功率密度和照射时间的激活规律。方法以454 nm激光器作为激发光源,通过改变光敏剂ATX-S10和HpD浓度,以及激光照射功率密度和照射时间,利用光电倍增管测量单态氧在波长1 270 nm处的红外发光强度变化情况,对比两种光敏剂的激活特性。结果浓度分别为5、10、30、50和100μg/ml的ATX-S10和HpD溶液,氩离子激光器照射后,单态氧的红外发光强度均随光敏剂浓度的增加而增加,光敏剂浓度相同时,ATX-S10比HpD发光强度更强;激光的功率密度越强,相对发光强度越高,相同辐照强度下,ATX-S10比HpD发光强度更强;辐射时间越长,相对发光强度越强,直至达到饱和(60 s),辐射时间相同时ATX-S10比HpD发光强度更强。结论激光功率密度越大、照射时间越长、光敏剂浓度越高,光敏剂的激活率越高。相同条件下ATX-S10的单态氧产率比HpD高。Objective To contrast the activated properties of two photosensitizers ATX-S10 and HpD at different concentration,power density or time by the laser. Methods Activating the photosensitizers using 454 nm laser,changing the photosensitizer concentration,power density or radiation time,to detect the luminescence intensity of singlet oxygen near 1 270 nm with the photomultiplier. Results At the concentration of 5,10,30,50 and 100 μg/ml,the luminescence intensity of ATX-S10 and HpD was raised with the increase in the photosensitizer concentration and radiation intensity after argon laser irradiation.While activating both of them at the same concentration and radiation intensity.The luminescence intensity of ATX-S10 was higher than HpD.Furthermore,the luminescence intensity of ATX-S10 and HpD increased with the prolong of radiation time until they reached saturation（60 s）. Conclusions The power density is stronger,the time is longer,the concentration is greater,the activated rate of the photosensitizers is better.Under the same conditions,the singlet oxygen yield of ATX-S10 is higher than HpD.

关 键 词：光敏剂 单态氧 发光强度 

分 类 号：R318.51[医药卫生—生物医学工程]