双氢青蒿素哌喹复方片治疗缅甸恶性疟的临床观察  

Efficacy of Compound Dihydroartemisinin/piperaquine in Treatment of Uncomplicated Falciparum Malaria in Myanmar

作　　者：刘慧[1] 杨恒林[1] 张军 李春富[1] 聂仁华[1] 王恒业[1] 

机构地区：[1]云南省寄生虫病防治所,云南省疟疾研究中心,大理学院病原与媒介生物学研究所,思茅665000 [2]英国无国界卫生组织云南代表处,昆明650000

出　　处：《中国寄生虫学与寄生虫病杂志》2011年第4期296-298,共3页Chinese Journal of Parasitology and Parasitic Diseases

摘　　要：目的观察双氢青蒿素哌喹复方片对缅甸无并发症恶性疟的疗效。方法 2007-2008年,分别在缅甸佤邦和克钦邦两个区,选择6～60岁无并发症、原虫无性体密度为500～200 000个/μl的单纯恶性疟病例,使用双氢青蒿素哌喹复方片治疗,成人总剂量8片(每片含双氢青蒿素40 mg,磷酸哌喹320 mg),儿童剂量按年龄递减,疗程3 d。观察患者的退热时间、原虫转阴时间、无性体清除情况和不良反应等。结果共完成治疗134例患者,平均退热时间为(25.5±2.8)h,平均原虫转阴时间为(39.5±7.8)h,无性体7 d清除率100%,治后28 d有4例复燃;16例在服药后出现中枢神经系统及胃肠道反应,如头痛、恶心、呕吐和腹泻等轻微症状,停药后即自行消失。结论双氢青蒿素哌喹复方片在缅甸治疗无并发症恶性疟效果良好。Objective To observe the therapeutic efficacy of compound dihydroartemisinin-piperaquine for treatment of uncomplicated falciparum malaria in Myanmar. Methods From 2007 to 2008, patients aged 6 to 60 years with uncomplicated P. falciparum infection and parasite density 500 to 200 000 parasites/ILl were enrolled following an informed consent. A three-day course of total 8 tablets compound dihydroartemisinin-piperaquine was administered to an adult （each tablet containing 40 mg of dihydroartemisinin and 320 mg of piperaquine phosphate）, dosage for children was based on ages （details in the treatment regimen） . The indices including fever subsiding time, parasite clearance time, asexual parasite clearance time and adverse clinical responses were observed and collected on days 7, 14, 21, and 28 after treatment. Results A total of 134 patients completed the treatment. The mean fever subsiding time and mean asexual parasite clearance time were （25.5±2.8） h and （39.5±7.8） h respectively. Asexual parasite clearance rate was 100% on day 7. Four cases recrudesced on day 28 and 16 cases had slight adverse clinical responses such as uncomfortable gastrointestinal tract, headache, nausea, vomit and diarrhea, which disappeared as soon as drug withdrawal. Conclusion The compound dihydroartemisinin/piperaquine shows a sound efficacy in treating uncomplicated falciparum malaria.

关 键 词：双氢青蒿素 磷酸哌喹复方片 缅甸 恶性疟 疗效 

分 类 号：R531.32[医药卫生—内科学]