SPECT放射性核素骨显像在转移性骨肿瘤放化疗疗效评价中的临床价值  

Clinical value of SPECT radionuclide bone imaging in efficacy evaluation of radiotherapy and chemotherapy in bone metastases

作　　者：杨宁[1] 左书耀[2] 王怀全 刘冬[1] 

机构地区：[1]山东省淄博市中心医院,山东淄博255036 [2]青岛大学医学院附属医院,山东青岛266003

出　　处：《中国中西医结合影像学杂志》2011年第4期314-317,共4页Chinese Imaging Journal of Integrated Traditional and Western Medicine

摘　　要：目的:探讨SPECT放射性核素骨显像在转移性骨肿瘤放化疗疗效评价中的应用价值。方法:60例转移性骨肿瘤患者分为:A组,放疗联合化疗;B组,单纯放疗。在治疗后第1、3、6个月分别行骨显像检查,观察疗效差异。结果:①A组治疗后第1、3、6个月的疗效分别为63.9%、72.7%、54.3%;B组分别为52.0%、61.9%、42.2%。2组均为第3个月疗效最高。②2组间治疗后3月的疗效比较,A组均比B组高,差异均有统计学意义。治疗后第3个月2组间不同部位的疗效A组均比B组高,胸部病灶疗效差异有统计学意义(P<0.01)。③治疗后第3个月2组间不同类型骨转移疗效A组均比B组高,乳腺癌骨转移的疗效差异有统计学意义(P<0.05)。结论:转移性骨肿瘤患者放化疗后定期的一系列骨显像检查对于其临床治疗决策的制订和调整具有较高的临床价值。Objective： To explore the value of SPECT radionuclide bone imaging in the efficacy evaluation of radiotherapy and chemotherapy in bone metastasis. Methods： Sixty patients with bone metastases, group A accepted radiotherapy combined with chemotherapy, group B accepted radiotherapy alone. After treatment completion 1, 3, 6 three months, bone imaging inspection was rechecked separately, observing the differences of the efficacy. Results：①The efficacy of the group A after treatment completion 1,3,6 three months were： 63.9%, 72.7% and 54.3% ; group B： 52.0%, 61.9% and 42.2%, respectively. The efficacy of the third month after treatment was better than the other two months in both group A and B. ②The efficacy after treatment 1,3,6 three months in the group A were better than that in the group B, the differences were statistically significant. The efficacy of the different parts of the third month after treatment in the group A were better than that in the group B, the differ- ence was statistically significant in the chest part （P〈0.01）.③The efficacy of the different types of bone metastases of the third month after treatment in the group A were better than that in the group B, the difference was statistically significant in the breast cancer bone metastases（P〈0.05）. Conclusion： There is high clinical application value of a series of regular bone imaging in patients with bone metastases for clinical decision making and readjustment after radiotherapyand chemotherapy.

关 键 词：骨肿瘤 肿瘤转移 体层摄影术 发射型计算机 

分 类 号：R738.1[医药卫生—肿瘤] R817[医药卫生—临床医学]