1例化妆品汞中毒相关肾病综合征临床病理分析  

Clinicopathological features of cosmetics mercury poisoning-related nephrotic syndrome:A case report

作　　者：李红艳[1] 魏日胞[2] 王远大[2] 杨勇[2] 

机构地区：[1]河南省人民医院急诊科,郑州450003 [2]解放军总医院肾科全军肾脏病研究所暨重点实验室

出　　处：《军医进修学院学报》2011年第9期975-977,共3页Academic Journal of Pla Postgraduate Medical School

基　　金：国家科技重大专项基金项目(2010ZX9102-204);国家自然科学基金项目(81072914);军队中医药专项课题(10ZYZ255)~~

摘　　要：目的探讨化妆品汞中毒相关肾病的临床病理特点及治疗方法。方法解放军总医院肾科2010年11月收治的1例女性化妆品汞中毒病例,分析其临床病理特点及对驱汞治疗的反应。结果该病例用含汞美白化妆品半年,临床表现为肾病综合征,血压及肾功能正常,血清自身抗体系列正常。病理特点表现为膜性肾病I期,患者未用免疫抑制剂,驱汞治疗效果较好,尿蛋白逐渐减少,全身症状改善。结论本例化妆品汞中毒相关肾病表现为肾病综合征,病理为膜性肾病I期,对驱汞治疗反应较好。Objective To study the clinicopathological features of cosmetics mercury poisoning-related nephropathy and its treatment methods. Methods Clinicopathological features of a female patient with cosmetics mercury poisoning-related nephropathy admitted to Department of Nephrology, Chinese PLA General Hospital, in November 2010 and her response to antimercurialism were analyzed. Results The patient developed nephritic syndrome after using whiten cosmetics that contains mercury for half a year. Her blood pressure, renal function, and serum autoantibody were normal. Pathologic examination showed stage 1 membranous nephropathy. The patient did receive any immunosuppressive agent. After antimercurialism, her urinary protein gradually decreased and systemic symptoms improved. Conclusion Cosmetics mercury-related nephropathy is manifested as nephrotic syndrome （which was diagnosed as stage I membranous nephropathy in this patient who had a rather good response to antimercurialism）.

关 键 词：汞中毒 肾病综合征 肾小球肾炎 驱汞治疗 

分 类 号：R692[医药卫生—泌尿科学]