电针对阿尔海茨默病模型大鼠跳台试验潜伏期和错误次数的影响及其相关机制研究  

Effects of Electroacupuncture on AD Rats Step-down Test Latencies and Error Frequency Effects and the Related Mechanism Research

作　　者：朱晓冬[1] 蒋希成[2] 毛翔[2] 

机构地区：[1]牡丹江医学院,黑龙江牡丹江157011 [2]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医学报》2011年第9期1139-1141,共3页Acta Chinese Medicine

基　　金：黑龙江省教育厅资助项目(编号:11541380)

摘　　要：目的:探讨电针对阿尔海茨默病模型大鼠运动能力的影响。方法:将通过筛选的模型大鼠分为空白对照组、模型对照组、模型组、西药组和电针组5组,电针组给予电针治疗,西药给予哈伯因灌液,其余三组每日给予相同容量的生理盐水,共治疗6周。观察各组大鼠跳台试验潜伏期和错误次数。结果:造模后模型组与空白组比较逃避潜伏期缩短,错误次数增多(P<0.01),电针组、西药组治疗后潜伏期较长,错误次数较少(P<0.05);治疗后,电针组、西药对照组较模型组海马CA1区tau蛋白表达表达水平显著增多(P<0.01)。结论:电针对AD大鼠记忆能力的恢复有重要的调节作用。Objective：To explore the effect of Electroacupuncture on the heights Alzheimer’s disease model rats locomotor effects.Methods：Through screening model rats were divided into control group,model control group,model group,electroacupuncture group and Western medicine group and a 5 group,electroacupuncture group was given acupuncture therapy,western medicine to give Hubble for filling,the remaining three group was given the same daily volumes of saline,a total of 6 weeks of treatment.Rats were observed step-down test latency and number of errors.Results：After modeling model group compared with normal group escape latency shortening,error number increase（P〈0.01）,electroacupuncture group,western medicine group after treatment with longer latency,number of errors less（P〈0.05）;after the treatment,the electroacupuncture group,western medicine group than those in the model group in hippocampal CA1 region of tau protein expression level significantly increased（P〈0.01）.Conclusion：Acupuncture on memory ability in rat AD recovery have important roles in the regulation of

关 键 词：阿尔海茨默病模型 电针 大鼠 跳台试验 

分 类 号：R245-3[医药卫生—针灸推拿学]