盐酸安非他酮的戒烟效果  

Efficacy of Bupropion Hydrochloride on Smoking Cessation

作　　者：吴承菊[1] 邢华[1] 杨洁[1] 

机构地区：[1]首都医科大学宣武医院职工保健科,北京市100053

出　　处：《职业与健康》2011年第17期1995-1996,共2页Occupation and Health

摘　　要：目的初步评价盐酸安非他酮戒除烟瘾的有效性和安全性。方法 43名受试者口服盐酸安非他酮缓释片150～300mg/d,疗程7周,观察12周。分别于服药前,服药后4周及12周进行问卷调查。结果 4周时的戒烟率为20.9%(9/43),12周时为34.9%(15/43)。随着服药时间延长,日吸烟量逐渐减少。烟草依赖自评量表结果显示12周时,各种戒断症状的发生率较4周时明显下降。观察期间出现的不良反应包括恶心(16.2%)、呕吐(2.3%)、异常梦境(4.7%)和情绪改变(7.0%)。没有受试者因为不良反应而停药。结论盐酸安非他酮对戒除烟瘾有一定的疗效,并且具有良好的安全性和可耐受性。[Objective]To evaluate the efficacy and safety of bupropion hydrochloride for smoking cessation. [Methods]43 subjects were treated with bupropion hydrochloride sustained-release tablet 150~300 mg/d for 7 weeks,and observed for 12 weeks.The questionnaire investigation was conducted before treatment,4 weeks and 12 weeks after treatment. [Results]The abstinence rate at the end of the 4th and 12th week was 20.9%（9/43） and 34.95（15/43） respectively.The daily consumption of cigarettes decreased with administration time.The results of self-rating scale of tobacco dependence showed that the incidence of withdrawal symptoms at the 12th week reduced significantly as compared with the 4th week.The common adverse reactions during the observation period included nausea（16.2%）,vomiting（2.3%）,abnormal dreams（4.7%） and mood change（7.0%）.No subject stopped treatment because of the adverse reaction. [Conclusion]Bupropion hydrochloride has a certain curative effect on smoking cessation,and has good safety and tolerability profile.

关 键 词：盐酸安非他酮 烟草依赖 药物疗法 安全性 有效性 

分 类 号：R163[医药卫生—公共卫生与预防医学]