不同因素致兔角膜烧伤后应用FGF-10治疗的形态计量学比较研究  

Morphometric Comparative Study of FGF-10 Treatment after Different Factors Induced Corneal Burns in Rabbits

作　　者：高荣莲[1] 马萍[1] 梁洁[1] 王丽峰[1] 陈鹏[1] 康宏向[1] 钱焕文[1] 

机构地区：[1]中国人民解放军军事医学科学院放射与辐射医学研究所,北京市100850

出　　处：《职业与健康》2011年第18期2041-2043,共3页Occupation and Health

基　　金：全军"十一五"医药卫生专项课题(项目编号:06Z063)

摘　　要：目的应用形态计量学方法观察成纤维细胞生长因子-10(Fibroblast growth factor-10,FGF-10)对碱和激光所致角膜烧伤的治疗作用。方法分别用NaOH溶液和CO2激光造成角膜烧伤模型,通过对烧伤斑图像分析和吸光度值测定,观察FGF-10的治疗作用。结果 FGF-10滴眼治疗可以缩小角膜烧伤斑的面积,促进角膜透明度的恢复。结论一定浓度的FGF-10对化学和物理因素所致角膜烧伤均具有明显的治疗作用。[Objective]To observe the therapeutic effect of Fibroblast growth factor-10（FGF-10） on alkali or laser induced corneal burns.[Methods]Rabbits corneas were burned by alkali or laser to form burn model.Image analysis and absorbance value measurement on burn spots were performed to observe the therapeutic effect of FGF-10.[Results]FGF-10 was beneficial to reduce the area of the corneal burns and to improve the recovery of corneal transparence.[Conclusion]A certain concentration of FGF-10 has therapeutic effect on corneal burn induced by both chemical and physical factors.

关 键 词：碱 激光 角膜 烧伤 成纤维细胞生长因子-10 

分 类 号：R965[医药卫生—药理学]