西洋参茎叶皂苷对局灶性脑缺血大鼠血清中S-100β含量的影响  

The Effect of Panax Quinquefolius Saponin on the S-100β Contents of Serum in Rats with Focal Cerebral Ischemia

作　　者：鲁美君[1] 关利新[2] 赵鑫[1] 王怀刚[1] 朱丹 朱孝娟[4] 苏云明[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]牡丹江医学院,黑龙江牡丹江157000 [3]齐齐哈尔市中医院,黑龙江齐齐哈尔161000 [4]哈尔滨医科大学,黑龙江哈尔滨150081

出　　处：《中医药信息》2011年第5期21-22,共2页Information on Traditional Chinese Medicine

基　　金：国家自然科学基金课题(30973897)

摘　　要：目的:观察西洋参茎叶皂苷(PS)对脑缺血大鼠血清中S-100β蛋白的影响,并进一步探讨其作用机制。方法:用线栓法制备大鼠局灶性脑缺血模型,采用酶联免疫法检测PQS对大鼠血清中S-100β蛋白含量的影响。结果:PQS能改善神经功能缺损的症状,降低血液中S-100β的含量。结论:PQS对大鼠脑缺血具有保护作用,其作用机制可能与星形胶质细胞的内源性保护作用有关。Objective： To observe panax quinquefolius saponin on cerebral ischemia in S-100β protein in serum and to further explore its mechanism.Methods： The rats with incomplete cerebral ischemia were induced with fishing line in the middle cerebral artery occlusion（MCAO）.PQS by ELISA on serum S-100β protein content.Result： PQS could improve the symptoms of neurological impairment,lower blood S-100β content.Conclusion： PQS has a protective effect on cerebral ischemia in rats.The mechanism may be related to endogenous astrocytes protective effects.

关 键 词：西洋参茎叶皂苷 局灶性脑缺血 S-100Β 

分 类 号：R285.5[医药卫生—中药学]