滇南小耳猪人工瓣膜置换模型的建立  

Establishment of Diannan small-ear pig models of artificial valve replacement

作　　者：黄栋[1] 张桂敏[2] 杨鸿生[3] 孙毅[2] 

机构地区：[1]昆明医学院心胸外科,云南省昆明市650000 [2]昆明医学院第一附属医院心脏外科,云南省昆明市650000 [3]云南省卫生厅,云南省昆明市650000

出　　处：《中国组织工程研究与临床康复》2011年第31期5835-5838,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科学基金资助项目(30860279);课题名称:瓣下结构对人工心瓣膜下游血流动力学影响的体内定量研究~~

摘　　要：背景:猪和人的心脏解剖结构特点相似,是研究心血管疾病的理想模型。目的:建立滇南小耳猪二尖瓣置换模型,应用心脏超声评估模型建立的可行性。方法:成年猪10头,均于体外循环下经左心耳径路行二尖瓣置换,人工瓣膜为St.Jude双叶机械瓣,采用3种置换方式,并以心脏超声分析瓣膜置换后2周小耳猪心脏结构和功能的变化。结果与结论:除1头因麻醉诱导期出现室颤死亡外其余均存活。心脏超声显示3种方式置换瓣膜后2周,猪心脏结构和功能与置换前无显著差异。人工机械瓣膜在猪体内的血流动力学和组织相容性均良好,二尖瓣置换前后猪的心脏结构及功能稳定。BACKGROUND：The pig’s heart is considered most anatomically similar to the human heart, and therefore is an ideal model for studying cardiovascular diseases. OBJECTIVE：To establish Diannan small-ear pig models of mitral valve replacement and investigate the feasibility of model establishment by cardiac ultrasonography. METHODS：Ten adult pigs underwent mitral valve replacement via the left atrial appendage under cardiopulmonary bypass through three replacement models. At 2 weeks after replacement, changes in cardiac structure and function were analyzed using cardiac ultrasonography. RESULTS AND CONCLUSION：One pig died for cardiopulmonary arrest during anesthesia induction. The remaining nine pigs survived after surgery. Cardiac ultrasonography showed that at 2 weeks after transplantation, there was no significant difference in cardiac structure and function compared with prior to transplantation, artificial valve showed good hemodynamics and histocompatibility in the pig’s body, and before and after transplantation, pig’s cardiac structure and function were stable.

关 键 词：猪 人工瓣膜 动物模型 二尖瓣置换 心脏超声 

分 类 号：R318[医药卫生—生物医学工程]