骨髓增生异常综合征83例患者染色体核型分析  

Analysis on karyotype of 83 cases of myelodysplastic syndrome

作　　者：徐萍[1] 王京华[1] 董家蔷[1] 郭敏[2] 张延清[1] 高海燕[1] 高杰[1] 

机构地区：[1]哈尔滨医科大学附属第二医院血液科,黑龙江哈尔滨150081 [2]首都医科大学附属北京朝阳区医院口腔科,北京100043

出　　处：《哈尔滨医科大学学报》2011年第4期380-381,384,共3页Journal of Harbin Medical University

摘　　要：目的探讨染色体核型分析在骨髓增生异常综合征(MDS)诊断、治疗及预后中的作用。方法采用骨髓直接法和24 h培养法,并用R显带技术,对83例MDS患者的染色体核型进行分析。结果 83例MDS患者中有46例患者染色体核型异常,异常检出率为55.4%,主要累及+8、5q-、-7、7q-、20q-及其它涉及数量或结构异常的各种核型改变;核型异常复杂的MDS患者易进展为急性白血病;6例MDS患者初诊时骨髓形态未见明显病态造血,而染色体有异常克隆。结论染色体核型分析在MDS的早期诊断、早期治疗和预后评估中具有重要价值。Objective To explore the value of karyotype analysis in myelodysplastics syndrome （MDS） for diagnosis, treatment and prognosis. Methods The karyotype analysis was performed for 83 patients with MDS using the direct method, 24-hour culture method and C-banding technique. Results Among 83 patients, 46 cases were found with abnormal karyotype. The abnormal rate was 55.4%. Abnormal chromosomes mainly showed ＋8, 5q , 7,7q - , 20q- and other abnormalities in quantity or structure. The patients with complicated chromosomal abnormalities tended to acute leukemia. Six cases without significant morphological dys- plasia in preliminary diagnosis were found clonal chromosomal abnormalities. Conclusion The karyotype analysis is very important for early diagnosis, early treatmeant and prognosis of MDS.

关 键 词：染色体 核型分析 骨髓增生异常综合征 

分 类 号：R551.3[医药卫生—血液循环系统疾病]