脂肪来源干细胞促进颗粒脂肪游离移植后再血管化的机制  

MECHANISM OF IMPROVED REVASCULARIZATION OF FREE FAT GRAFTING WITH ADIPOSE-DERIVED STEM CELLS

作　　者：袁艺[1] 鲁峰[1] 高建华[1] 

机构地区：[1]南方医科大学南方医院整形外科,广州510515

出　　处：《中国修复重建外科杂志》2011年第9期1125-1129,共5页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(30901566;81071589);广东省自然科学基金资助项目(9151051501000025)~~

摘　　要：目的对脂肪来源干细胞(adipose-derived stem cells,ADSCs)促进颗粒脂肪游离移植后再血管化的机制进行综述。方法查阅近年有关ADSCs在游离脂肪移植和血管形成中的基础研究文献并进行综述。结果血管形成在时间和空间是一个序惯发生的过程,受到多种因素调控。ADSCs能分泌多种促血管生成因子,并且具有多向分化的潜能。结论 ADSCs作用于血管生成过程的每个部分,具有明确的促血管生成作用,但具体机制仍需要进一步研究。Objective To review the mechanism of improved revascularization of free fat grafting with adipose-derived stem cells（ADSCs）.Methods The literature related to the basic researches of ADSCs in free fat grafting and angiogenesis was reviewed.Results Angiogenesis is a sequence process in time and space which is regulated by various factors.ADSCs possess the capability of secreting many angiogenic growth factors and differentiating into various lineages.Conclusion ADSCs affect every process of angiogenic effects need the further researches.

关 键 词：脂肪来源干细胞 脂肪游离移植 再血管化 机制 

分 类 号：R622.9[医药卫生—整形外科]