皮下埋植系统与2型糖尿病治疗  

Subcutaneous Implanted System for the Treatment of Type 2 Diabetes

作　　者：李艳[1] 郭晖[1] 

机构地区：[1]吉林大学白求恩第一医院二部内分泌科,长春130031

出　　处：《中国医学科学院学报》2011年第4期473-477,共5页Acta Academiae Medicinae Sinicae

摘　　要：2型糖尿病是一种代谢失调性疾病,以胰岛素分泌不足和胰岛素抵抗为特点。胰岛素治疗已经成为糖尿病治疗的重要手段,但是长期注射胰岛素不仅不便,还会引起局部脂肪组织萎缩和硬结。因此,新的给药方式是目前一大研究热点,主要包括改进注射给药系统、研制新的基因重组胰岛素和改变给药途径等。本文介绍了皮下埋植系统这一新的给药途径。Type 2 diabetes is a complex metabolic disorder characterized by hyperglycemia arising from a combination of insufficient insulin secretion and resistance to insulin action.Insulin has become an important agent in treating this disease,but long-term administration of insulin not only brings pain and inconvenience to the patients but also causes local adipose tissue atrophy and scleroma.Therefore,novel delivery method has become a hot topic,mainly including improving delivery systems,developing new recombinant insulin,and changing the route of administration.This article introduces DUROS（an implanted delivery system）,a new route of drug administration.

关 键 词：糖尿病 胰岛素 胰高糖素样肽-1 皮下埋植系统 

分 类 号：R587.1[医药卫生—内分泌]