413例儿童哮喘危险因素Logistic回归分析  

Logistic regression analysis of correlative factors for 413 asthma children

作　　者：陈建平[1] 赵婉莹[2] 何念海[1] 周平[1] 王刚[1] 汪万军[1] 

机构地区：[1]第三军医大学西南医院儿科,重庆400038 [2]西安交通大学医学院第一附属医院消化内科,西安710061

出　　处：《第三军医大学学报》2011年第17期1862-1864,共3页Journal of Third Military Medical University

基　　金：国家自然科学基金面上项目(30600686);重庆市自然科学基金(CSTC2007BB5062)~~

摘　　要：目的调查重庆地区儿童哮喘发病的相关因素,为本地区儿童哮喘的防治提供参考。方法第三军医大学西南医院儿科哮喘门诊或儿科病房2007年6月至2010年12月期间哮喘儿童413例,采取数字随机法选取同期来院体检及就诊非哮喘的儿童420例作为对照。通过问卷调查和做相应检查,追溯哮喘病史并随访其治疗情况,寻找哮喘发病的相关因素。结果调查10个相关因素,经非条件Logistic回归分析,最终发现6个危险因素和2个保护因素,其中家族遗传性、特应性体质、皮肤点刺阳性、总IgE是儿童哮喘的高危因素。结论遗传因素与哮喘密切相关,特应性体质是儿童哮喘的危险因素。母乳喂养和HAV感染为儿童哮喘保护因素。Objective To study the correlative factors for asthma children in Chongqing,China.Methods This study enrolled 413 children with asthma from the Pediatric Asthma Outpatient Department and Pediatric Ward of Southwest Hospital of Third Military Medical University from Jun.2007 to Dec.2010.The control group included 420 children without asthma from the outpatients and the children who accepted physical examination in our hospital.Questionnaires,examinations,asthma history analysis and following-up were used to determine the correlative factors for asthma children.Results Totally 10 factors were investigated and analyzed by Logistic regression analysis.Two factors were excluded and eight factors were included in the end,and among the eight factors there were six risk factors and two protective factors.High risk factors included heredofamilial asthma,atopic constitution,positive response to skin prick test（SPT）,and high total IgE level.Conclusion Genetic factors are closely correlated with the development of asthma children,and atopic constitution is a risk factor for asthma children.Protective factors include breastfeeding and hepatitis A virus（HAV） infection.

关 键 词：哮喘 危险因素 保护因素 儿童 

分 类 号：R725.622.5[医药卫生—儿科] R195.4[医药卫生—临床医学]