神经干细胞移植等方法治疗脑梗死后遗症的策略研究  

Strategy study of treatment for cerebral infarction sequelae using neural stem cell transplantation

作　　者：陈小玉[1] 段云霞[1] 方亮[2] 张梓倩[1] 刘庆山[1] 

机构地区：[1]中央民族大学中国少数民族医学研究院,北京市100081 [2]苏州大学体育学院,江苏省苏州市215021

出　　处：《中国组织工程研究与临床康复》2011年第14期2633-2636,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科学基金面上项目(NO30973959;NO20962012);中央民族大学自主科研计划项目(NO0910KYXJ12);中央民族大学211工程三期创新人才培养项目(NO0212110309100435)~~

摘　　要：背景:国内外动物模型的研究已经表明干细胞移植对脑梗死的治疗可以起到积极作用,在行为恢复和缩小梗死面积临床试验也有一定的成果。目的:通过分析和总结2000年以来国内外多种方法治疗脑梗死后遗症的研究,探讨各疗法的优缺点,寻求最佳的治疗途径。方法:分别以"脑梗死后遗症、脑卒中后遗症","Cerebral infarction sequelae hemiplegia"等为检索词,应用计算机检索万方数据知识服务平台及Pubmed数据库2000-01/2010-10有关文章,保留22篇文献做进一步分析。结果与结论:神经干细胞治疗脑梗死后遗症的方法主要集中在外源性神经干细胞移植后整合、补充或替代受损及内源性神经干细胞损伤后在细胞因子等的作用下激活修复。神经保护疗法主要是针对缺血性级联反应的各种通路,保护因缺血、缺氧而受损伤但仍有活力的神经元,逆转半暗带,降低再灌注损伤对脑神经细胞的损伤,减少梗死面积,进行有针对性的治疗。理疗及功能康复、民族药物多种方法的应用也为脑梗死后遗症的治疗带来了希望。其中调节在体神经干细胞增殖和分化,促进神经系统的功能修复是未来药物研究的重要研究目标。BACKGROUND：Studies have demonstrated that stem cell transplantation plays a positive role in treatment of cerebral infarction,which also has good outcome in recovery and diminution of infarct size in clinical trials.OBJECTIVE：By analyzing and summarizing the research which adopts treatment of cerebral infarction sequelae in past ten years,we devote to discuss the strength and weakness of those treatments and find a suitable treatment of cerebral infarction sequelae.METHODS：Application of computer technology to retrieve the articles in wanfang data and PubMed database on spinal cord tissue engineering from 2000 January to 2010 October.Words for retrieve were ＂cerebral infarction sequelae,neural stem cells＂.Twenty-two literatures were remained for analysis.RESULTS AND CONCLUSION：Neural stem cell transplantation for treating cerebral infarction sequelae are focus on integration,supplementation,or substitution damaged cells by transplanting exogenous neural stem cells,activation or repair injured endogenous neural stem cells.Neuroprotection aims directly at various passageways during ischemic cascade reactions,protects neurons which damaged by ischemia or hypoxia but has viable to reverse ischemic penumbra,decreases reperfusion injury,and reduces infarct size.Applications of physical therapy,functional rehabilitation and ethnic medicine provide new hope for treatment of cerebral infarction sequelae.How to regulate proliferation and differentiation of neural stem cells in vivo and promote neurologic repair is the research focus.

关 键 词：脑梗死后遗症 神经干细胞 神经保护 理疗 民族药物 

分 类 号：R318[医药卫生—生物医学工程]