热化学法制备CaTiO_3涂层及涂层的生物相容性  

Biocompatibility of calcium-titanate coating prepared by thermochemical treatment

作　　者：黄晶[1] 蓝琳[1] 肖东琴[1] 罗会涛[1] 智伟[1] 段可[1] 翁杰[1] 张聪 

机构地区：[1]西南交通大学材料科学与工程学院,材料先进技术教育部重点实验室,四川省成都市610031 [2]解放军第四五二医院,四川省成都市610021

出　　处：《中国组织工程研究与临床康复》2011年第16期2901-2904,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科学基金(30870630,81071456);全军"十一五"科技攻关课题(06G049);西南交通大学青年教师科研起步项目(209Q007)~~

摘　　要：背景:钛酸钙(CaTiO3)作为一种有前途的涂层,可应用于钛基医用植入体表面。目的:通过一种简单的热化学处理技术,在Ti6Al4V基体上制备均匀的CaTiO3涂层,同时通过培养成骨细胞观察涂层生物相容性。方法:通过将Ti6Al4V基体埋于无水硝酸钙(Ca(NO3)2)粉末中,并且升高温度;当温度处在Ca(NO3)2熔点以上时,在Ti6Al4V基体上能够生成一层均匀的CaTiO3层。同时在热化学处理温度为570℃的Ti6Al4V基体材料上进行成骨细胞培养,观察所制备涂层的生物相容性。结果与结论:该涂层转化只有在Ca(NO3)2熔点(561℃)以上时才会发生,同时随着处理温度的升高,CaTiO3晶体尺寸随之增大;经过热化学处理后的样品具有良好的生物相容性,对成骨细胞黏附、增殖具有更好的促进作用。该方法简单、有效,所制备的涂层具有良好的生物相容性,有望在钛植入体表面处理中获得应用,以提高金属表面与细胞、组织的相容性。BACKGROUND： Calcium-titanate （CaTiO3） is a promising coating candidate on titanium biomedical implants. OBJECTIVE： To prepare uniform CaTiO3 coatings on Ti6Al4V substrates by a simple thermochemical surface transformation technique and to evaluate its biocompatibility by in vitro culture of rat osteoblasts. METHODS： Ti6Al4V substrates were embedded in anhydrous calcium nitrate powders and the temperature was increased; reaction between the molten nitrate and Ti6Al4V formed a uniform layer of calcium nitrate. The biocompatibility of Ti6Al4V thermochemically treated at 570 ℃ was evaluted by in vitro culture of SD rat osteoblasts. RESULTS AND CONCLUSION： The transformation occurred only above the melting point of anhydrous calcium nitrate （561℃）, and that the size of the calcium titanate crystals increased with the treatment temperature. Proliferation and adhesion of osteoblasts was promoted on the thermochemically treated substrates. This technique is simple and efficient, and may find applications in the surface processing of titanium implants and improve. the biocompatibility between metals and cells or tissues.

关 键 词：钛酸钙 钛合金 涂层 热化学处理 成骨细胞 

分 类 号：R318[医药卫生—生物医学工程]