慢性硬膜下血肿液中VEGF、D-二聚体的测定及意义  

Assay of VEGF and D-dimer and their Significance in Chronic Subdural Hematoma

作　　者：任东坡[1] 蔺志清[1] 

机构地区：[1]宁波市第一医院神经外科,315000

出　　处：《临床神经外科杂志》2011年第4期195-196,共2页Journal of Clinical Neurosurgery

摘　　要：目的探讨血肿液中血管内皮生长因子(VEGF)、D-二聚体的含量与慢性硬膜下血肿(CSDH)发生发展的关系。方法利用酶联免疫吸附分析法(ELISA)及免疫散射比浊法对CSDH患者血肿液和血清中VEGF、D-二聚体的含量进行测定。结果血肿液中VEGF、D-二聚体的含量明显高于血清中的含量(P<0.001)。结论 VEGF、D-二聚体在慢性硬膜下血肿的发病机制中起重要作用。Objective To investigate the role of vascular endothelial growth factor （VEGF） and D-dimer in the pathogenesis of chronic subdural hematoma（CSDH）. Methods The concentrations of VEGF and D-dimer in hematoma fluid and serum in patients with CSDH were detected by enzyme 1 inked immunosorbent assay （ELISA） and immunoassay. Results The concentrations of VEGF and D-direct in the hematoma fluid were significantly increased compared with that in the serum （P 〈 0.001 ）. Conclusion VEGF and D-direct may play an important role in the pathogenesis of CSDH.

关 键 词：血管内皮生长因子 D-二聚体 慢性硬膜下血肿 

分 类 号：R651.15[医药卫生—外科学]