Tei指数与常规超声心动图指标评价甲亢患者左心功能的对比性研究  

Comparative study of conventional ultrasound index and Tei index in assessing left ventricular function of patients with hyperthyroid

作　　者：唐文峰[1] 范存芳[2] 

机构地区：[1]济南钢铁集团总公司总医院心内科,山东济南250101 [2]山东省荣军总医院特检科,山东济南250013

出　　处：《中国医药导报》2011年第26期43-46,共4页China Medical Herald

摘　　要：目的:探讨Tei指数评价甲状腺功能亢进症(甲亢)患者左室收缩及舒张功能的临床价值。方法:将临床确诊为甲亢的63例患者根据临床表现和辅助检查分为单纯甲亢组(n=35)和甲亢心组(n=28),进行常规超声心动图检查,测量左室舒张末期内径(LVDD)、左室收缩末期内径(LVSD)、室间隔厚度(IVST)、左室后壁厚度(LVPWT),测算出左室射血分数(LVEF)和左室短轴缩短率(LVFS);二尖瓣瓣口血流频谱舒张早期血流峰值速度E,舒张晚期血流峰值速度A及E/A;Tei指数。并与正常对照组(n=34)进行对比分析。结果:①与正常对照组和单纯甲亢组相比,甲亢心组的LVDD、LVSD显著增加,差异有统计学意义(P<0.05)。②与正常对照组和单纯甲亢组相比,甲亢心组的LVEF及LVFS显著降低,差异有统计学意义(P<0.05)。③甲亢心组的E峰明显低于正常对照组和单纯甲亢组,差异有统计学意义(P<0.05)。甲亢心组的A峰明显高于正常对照组和单纯甲亢组,差异有统计学意义(P<0.05)。而甲亢心组的E/A值降低,与正常对照组和单纯甲亢组比较,差异有统计学意义(P<0.05)。④甲亢各组的Tei指数较正常对照组均升高,甲亢心组高于单纯甲亢组,差异均有统计学意义(均P<0.05)。结论:甲亢患者早期即有收缩及舒张功能改变;Tei指数能敏感、客观、无创、早期评价甲亢患者的左室收缩功能和舒张功能的异常。Objective： To explore the clinical value of Tel index in assessing the left ventricular function in patients with hyperthyroid. Methods： 63 patients with hyperthyroid were divided into two groups by clinical symptoms and results of laboratory examination： simple hyperthyroid group （n=35） and hyperthyroid heart disease group （n=28）, and they were test- ed by ultrasonic cardiogram. Left ventricular end-diastolic diameter （LVDD）, left ventricular end systolic diameter （LVSD）, interventricular septum thickness （IVST）, left ventricnlar posterior wall thickness （LVPWT）, left ventricnlar ejection fraction （LVEF）, fractional shortening （LVFS）, early diastolic peak flow velocity E, late diastolic peak flow velocity A, E/A and Tie index were measured. And they were compared with those of normal control group （n=34）. Results： ①Compared with normal control group and simple hyperthyroid group, LVDD, LVSD in hyperthyroid heart disease group were significantly larger （P〈0.05）. ②Compared with normal control group and simple hyperthyroid group, LVEF and LVFS in hyperthyroid heart disease group were significantly lower （P〈0.05）. ③Hyperthyroidism heart group＇s E peak was significantly lower than that of normal control group and simple hyperthyroidism group （P〈0.05）; Hyperthyroidism heart group＇s A peak was significantly higher than that of normal control group and simple hyperthyroidism group （P〈0.05）; Compared with the normal control group and simple hyperthyroidism group, the hyperthyroidism heart group＇s E/A decreased （P〈0.05）. ④Both hyperthyroidism groups＇ Tel index increased, and hyperthyroid heart disease group was higher than simple hyperthyroid group （P〈0.05）. Condusion： Left ventrieular systolic and diastolic function of patients with hyperthyroidism decline in the early stage. Tel index can he sensitive, objective, non-invasive, early to detect the changes of left ventricular systolic and diastolic function in patients with h

关 键 词：TEI指数 甲状腺功能亢进症 甲亢心 左心功能 

分 类 号：R540.45[医药卫生—心血管疾病]